Category: 109-12-6

Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. One of the three diazines (six-membered heterocyclics with two nitrogen atoms in the ring), it has the nitrogen atoms at positions 1 and 3 in the ring. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. COA of Formula: C4H5N3.

Obot, I. B.;Bahraq, Ashraf A.;Alamri, Aeshah H. research published 《 Density functional theory and molecular dynamics simulation of the corrosive particle diffusion in pyrimidine and its derivatives films》, the research content is summarized as follows. The search and discovery of corrosion inhibitors to mitigate sweet corrosion in the oil and gas industry has been carried out mainly using tedious and costly exptl. approaches. In this study, theor. approach using d. functional theory (DFT) and mol. dynamics (MD) simulation were utilized to investigate the adsorption and diffusion properties of pyrimidine and six (6) of its derivatives on carbon steel corrosion in simulated CO₂-containing environment. The DFT calculations revealed that the electrons can easily flow from the HOMO orbitals of all the pyrimidine mols. to the empty substrate orbitals until reaching the equilibrium state as the values of EHOMO (-7.63 to -5.55 eV) are much higher than the Fermi level energy of Fe (-13.16 eV). Besides, the binding energy of mols. on the Fe (110) surface obtained using MD simulation was found to be in the range of 60.67 to 99.28 kcal/mol, indicating the pyrimidine mols. can strongly interact with the iron atoms of the metal surface. In the sweet medium, the diffusion coefficient (D) of HCO₃– was in the range of 0.81 to 1.41 m² s^-1, which is about three times less than the diffusion coefficient of HCO₃– in water. Self-diffusion coefficient (D’), and fractional free volume (FFV) were used to further investigate the diffusion mechanism of the pyrimidine mols. in CO₂ corrosive medium. Pyrimidine containing carboxylic acid and thioamide groups gave the best result as CO₂ corrosion inhibitor theor. The DFT and MD results provided useful insights and a theor. basis for the screening and design of new sweet corrosion inhibitors for carbon steel.

COA of Formula: C4H5N3, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., 109-12-6.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. It is also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Quality Control of 109-12-6.

Olyaei, Abolfazl;Abediha, Shohreh;Sadeghpour, Mahdieh;Adl, Alireza research published 《 An Efficient One-Pot Pseudo Five-Component Synthesis of Bis-heteroarylaminomethylnaphthoquinone Mannich Bases from Lawsone》, the research content is summarized as follows. A new series of bis-heteroarylaminomethylnaphthoquinone Mannich bases I (R = 4-methylpyridin-2-yl, benzothiazol-2-yl, pyrimidin-2-yl, etc.) have been synthesized through facial and efficient one-pot pseudo five-component reactions of lawsone, different heteroaryl amines RNH₂ and terephthaldehyde using p-TSA as catalyst in CH₃CN under reflux conditions. The high yields of products, very simple operation, readily available starting materials, high atom-economy, easy workup procedure and isolation/purification of target products without chromatog. are the main benefits of this synthetic strategy.

109-12-6, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., Quality Control of 109-12-6

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. It is also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Safety of Pyrimidin-2-amine.

Olyaei, Abolfazl;Mohamadi, Amir;Rahmani, Nilufar research published 《 Green synthesis of new lawsone enaminones and their Z/E(C=C)-isomerization induced by organic solvent》, the research content is summarized as follows. The synthesis of a new class of lawsone enaminone derivatives by using lawsone, tri-Et orthoformate and aromatic amines in the presence of guanidinium chloride under solvent-free conditions was developed. Investigation of ¹H-NMR spectra indicated that lawsone enaminones exist in the ketoenamine tautomeric form and underwent Z/E-isomerization with respect to the C=C bond in DMSO-d₆ at room temperature Furthermore, intramol. hydrogen bonds were observed in the synthesized compounds This method has some advantages including short reaction times, high to excellent yields, simple work-up procedure and very easy purification of products by non-chromatog. methods.

109-12-6, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., Safety of Pyrimidin-2-amine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. One of the three diazines (six-membered heterocyclics with two nitrogen atoms in the ring), it has the nitrogen atoms at positions 1 and 3 in the ring. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. Synthetic Route of 109-12-6.

Orlova, M. A.;Spiridonov, V. V.;Orlov, A. P.;Zolotova, N. S.;Lupatov, A. Yu.;Trofimova, T. P.;Kalmykov, S. N.;Yaroslavov, A. A. research published 《 Complexes of carboxymethylcellulose with Cu²⁺-ions as a prototype of antitumor agent》, the research content is summarized as follows. The search for new promising carries and vectors for the purposes of nuclear medicine with multifunctional effects is the most difficult problem in this branch of medicine. Among the components that are used to create carriers, one of the most perspective is the polysaccharide CM-cellulose (CMC). This choice is due to CMC high solubility in aqueous and saline solutions, low toxicity, high biocompatibility, as well as the content of a large number of anionic (carboxyl) and hydroxyl functional groups, which are capable of strong binding of polyvalent metal ions. In our work CMC were bound to Cu²⁺ ions that resulted in a collapse of the polymer macromol. and formation of the CMC- Cu²⁺ binary complexes. The binary complexes addnl. adsorbed 2-aminopyrimidine (AP) and formed the CMC- Cu²⁺-AP ternary complexes. The binary and ternary complexes were characterized by dynamic light scattering, laser electrophoresis, UV-spectrophotometry, TEM- microscopy, thin layer chromatog. and cell viability with the following main conclusions: (a) An increase in the copper content from up to 20 wt% leads to altering the size of CMC particles in water solution from 400 to 340 nm. Further binding of AP has no effect on the particle size. (b) In physiol. solution, the size of the ternary complex particles was addnl. decreased down to 200-220 nm. (c) The complex particles are stable against aggregation in water surrounding due to their total neg. charge. (d) Their cytotoxicity in relation to leukemic cells significantly exceeds that in relation to normal lymphocytes, creating an attractive therapeutic window. The results show good prospects for the CMC-copper complexes as drug carriers.

Synthetic Route of 109-12-6, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., 109-12-6.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. It is also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. COA of Formula: C4H5N3.

Mekala, Janaki Ramaiah;Ramalingam, Prasanna Srinivasan;Mathavan, Sivagami;Yamajala, Rajesh B. R. D.;Moparthi, Nageswara Rao;Kurappalli, Rohil Kumar;Manyam, Rajasekhar Reddy research published 《 Synthesis, in vitro and structural aspects of cap substituted Suberoylanilide hydroxamic acid analogs as potential inducers of apoptosis in Glioblastoma cancer cells via HDAC /microRNA regulation》, the research content is summarized as follows. Glioblastoma multiforme (GBM) is a heterogeneous, aggressive brain cancer characterized by chemo-resistance and cancer stemness. Histone deacetylases (HDACs) are a group of enzymes that regulate chromatin epigenetics which were in turn found to be controlled by microRNAs (miRs). The drug employed in chemotherapy for the treatment of GBM is Temozolomide (TMZ). Unfortunately, many GBM patients exhibit chemo-resistance to this drug. Here we have synthesized various Suberoyl anilide hydroxamic acid (SAHA) analogs with many substitutions at the cap site majority of which not yet studied. These SAHA analogs have exhibited profound cytotoxicity at 2 μM, and 4 μM concentrations in GBM cancer cell line U87MG, and 1 μM, and 2 μM concentrations in breast cancer cell line MCF-7. Surprisingly, these analogs have exhibited cytotoxic effects in chronic lymphoid leukemia cells (Raji) at 64 μM, and 128 μM concentrations due to mutated p53. Among all the synthesized analogs 3-Chloro-SAHA, 3-Chloro-4-fluoro SAHA have exhibited effective cytotoxicity in all cancer cells. These potent analogs inhibited HDAC-8 enzyme activity by 2-folds in U87MG, and MCF-7 cell lines and 7-folds decrease in HDAC-8 activity was observed in Raji cell line. These analogs decreased the expression of HDAC-2, HDAC-3 genes and enhanced the expression of p53 tumor suppressor. Interestingly, these compounds decreased the expression of Rictor, the main component of the mTORC2 complex involved cancer cell metabolism Furthermore, these mols. have decreased oncogenic microRNA expression such as miR-21 and enhanced the expression of tumor suppressor microRNAs such as miR-143. The HDAC binding ability of these mols. was highly significant and have exhibited the ability to cross blood-brain barrier (BBB), and followed the Lipinski rule of five. Thus, these mols. need to be taken up further to clinics for better therapy against GBM either singly or combination therapy.

109-12-6, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., COA of Formula: C4H5N3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Pyrimidine is a nitrogenous base similar to benzene (a six-membered ring) and includes cytosine, thymine, and uracil as bases used for DNA or RNA. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. SDS of cas: 109-12-6.

Mettu, Akhila;Talla, Venu;Naikal, Subhashini James Prameela research published 《 Novel anticancer Hsp90 inhibitor disubstituted pyrazolyl 2-aminopyrimidine compound 7t induces cell cycle arrest and apoptosis via mitochondrial pathway in MCF-7 cells》, the research content is summarized as follows. Compound 7t, 4-(4-bromophenyl)-6-(1-(4-chlorophenyl)-3-(4-nitrophenyl)-1H-pyrazol-4-yl) pyrimidin-2-amine, is a proven potent anticancer agent exhibiting Hsp90 inhibition in our previous studies. Herein, we explored the apoptotic potential of compound 7t by Annexin V assay. The mechanism underlining the apoptosis process is elucidated. As a potent Hsp90 inhibitor, compound 7t would induce the mitochondrial stress leading to increased permeability of its membrane, that would subsequently initiate the apoptosis in MCF-7 cells. This was proven by increased J-monomer formation using JC-1 stain. Moreover, due to the impaired mitochondrial function, compound 7t also exaggerated the apoptosis process by ROS generation as proved by DCFDA staining. The morphol. and nuclear changes in MCF-7 cells following apoptosis were identified by AO/EB and DAPI staining techniques. It also induced subG1 phase cell cycle arrest. Thus, compound 7t could serve as potential drug in the treatment regimen of breast cancer.

SDS of cas: 109-12-6, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., 109-12-6.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The nomenclature of pyrimidines is straightforward. However, like other heterocyclics, tautomeric hydroxyl groups yield complications since they exist primarily in the cyclic amide form. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. For example, 2-hydroxypyrimidine is more properly named 2-pyrimidone. A partial list of trivial names of various pyrimidines exists. Recommanded Product: Pyrimidin-2-amine.

Mouffok, Meryem;Abdelmalek, Ilham;Mesli, Abderrezzak;Moulay, Awatif Amaria research published 《 Investigation of Factors Affecting Particle Size Distribution and Sustained Release of a Water-Soluble Drug from Cellulose Derivatives Microspheres》, the research content is summarized as follows. Microspheres loaded by 2-aminopyrimidine (2-AP) and based on cellulose derivatives as polymeric matrixes: ethylcellulose (EC) and cellulose acetate butyrate (CAB), were prepared by double emulsion solvent evaporation method (w/o/w). The main objective of this research is to conceptualize the fabrication of new formulations with high encapsulation efficiency and a large range of size for a controlled drug release of a water-soluble drug. The effects of the process variables, namely, nature of the matrix, stirring speed, surfactant nature and concentration on the mean particle size and distribution, drug loaded, encapsulation efficiency and drug release were investigated. The microspheres were characterized by SEM, optical microscopy, FT-IR spectroscopy and the size and size distribution (δ) were determined SEM images showed spherical and porous microspheres with different structures. We have obtained systems with large ranges of size (d32, 45-219 μm with EC; d32, 37-160 μm with CAB using Polyvinyl alc. (PVA) as emulsifier; and d32, 294-779 μm with Tween 80) by modifying the process parameters. Furthermore, the mean diameter d32 and the dispersion can be controlled particularly by stirring speed of emulsion and the emulsifier nature and concentration The drug entrapment and encapsulation efficiency were improved by controlling certain factors, especially by using PVA as a stabilizer in the continuous phase, by increasing PVA concentration (2% PVA) and when using EC as a matrix. The drug release was established in simulated gastric medium at pH 1.2 and 37 °C by UV-Vis anal. to estimate the drug content. The kinetics results revealed that the drug release is governed by the diffusion mechanism and the release rate can be adjusted by varying the encapsulation factors that have a significant effect on the particle size and size distribution.

Recommanded Product: Pyrimidin-2-amine, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., 109-12-6.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. One of the three diazines (six-membered heterocyclics with two nitrogen atoms in the ring), it has the nitrogen atoms at positions 1 and 3 in the ring. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. Synthetic Route of 109-12-6.

Moutaoukil, Zakaria;Serrano-Diez, Emmanuel;Collado, Isidro G.;Jimenez-Tenorio, Manuel;Botubol-Ares, Jose Manuel research published 《 N-Alkylation of organonitrogen compounds catalyzed by methylene-linked bis-NHC half-sandwich ruthenium complexes》, the research content is summarized as follows. An efficient ruthenium-catalyzed N-alkylation of amines, amides and sulfonamides was developed employing novel pentamethylcyclopentadienylruthenium(II) complexes bearing the methylene linked bis(NHC) ligand bis(3-methylimidazol-2-ylidene)methane. The acetonitrile complex I was proved to be particularly effective with a broad range of substrates with low catalyst loading (0.1-2.5 mol%) and high functional group tolerance under mild conditions. A total of 52 N-alkylated organonitrogen compounds including biol. relevant scaffolds were synthesized from (hetero)aromatic and aliphatic amines, amides and sulfonamides using alcs. or diols as alkylating agents in up to 99% isolated yield, even on gram-scale reactions. In the case of sulfonamides, it was the first example of N-alkylation employing a transition-metal complex bearing NHC ligands.

109-12-6, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., Synthetic Route of 109-12-6

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Pyrimidine is a nitrogenous base similar to benzene (a six-membered ring) and includes cytosine, thymine, and uracil as bases used for DNA or RNA. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Reference of 109-12-6.

Lu, Yu-Xiang;Song, Hai-Liang;Chand, Hameer;Wu, You;Yang, Yu-Li;Yang, Xiao-Li research published 《 New insights into the role of molecular structures on the fate and behavior of antibiotics in an osmotic membrane bioreactor》, the research content is summarized as follows. Osmotic membrane bioreactors (OMBRs) have been applied to enhance removal of antibiotics, however, information on the effects of mol. structures on the behavior of antibiotics is still lacking. Herein, adsorption kinetics, transformation pathways, and membrane rejection mechanisms of OMBRs were investigated by adding two typical antibiotics (i.e., sulfadiazine, SDZ, and tetracycline hydrochloride, TC-HCl). 80.70-91.12% of TC-HCl was removed by adsorption and biodegradation, while 17.50-75.14% of SDZ was removed by membrane rejection; this depended on its concentration due to reduced electrostatic interactions and hydrophobic adsorption. The adsorption capacity of TC-HCl (i.e., 1.34±0.01 mg/g) was significantly higher than that of SDZ (i.e., 0.18±0.03 mg/g) due to enhanced π-π interactions, hydrogen bonding and improved electrostatic interactions. The abundant production of polysaccharide-like substances from TC-HCl biodegradation contributed to microbial metabolism and thus enhanced microbial function during TC-HCl biotransformation. The primary degradation pathways were determined by microbial function anal., and the primary intermediates from TC-HCl degradation were less toxic than those from SDZ degradation due to the different reactions of amino groups. These results and the corresponding mechanism provide a theor. foundation for the further development of OMBR technol. for highly efficient treatment of antibiotic wastewater.

109-12-6, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., Reference of 109-12-6

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The systematic study of pyrimidines began in 1884 with Pinner, who synthesized derivatives by condensing ethyl acetoacetate with amidines. Pinner first proposed the name “pyrimidin” in 1885. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. The parent compound was first prepared by Gabriel and Colman in 1900, by conversion of barbituric acid to 2,4,6-trichloropyrimidine followed by reduction using zinc dust in hot water. Name: Pyrimidin-2-amine.

Ma, Dongmei;Yang, Yang;Liu, Bingfeng;Xie, Guojun;Chen, Chuan;Ren, Nanqi;Xing, Defeng research published 《 Zero-valent iron and biochar composite with high specific surface area via K₂FeO₄ fabrication enhances sulfadiazine removal by persulfate activation》, the research content is summarized as follows. Zero-valent iron and biochar composite (ZVI/BC) is a prospective catalyst for activating persulfate and sp. surface area (SSA) of ZVI/BC is one of the most important factors affecting its efficacy in the removal of environmental contaminants. However, the green fabrication of ZVI/BC with large SSA remains a challenge. In this study, ZVI/BC with a highly porous structure and large SSA fabricated by co-pyrolysis of K₂FeO₄ and bamboo was prepared and characterized. The large SSA stemmed from the catalytic and corrosive functions of K and the oxidation of K₂FeO₄ onto bamboo. ZVI/BC fabricated with 0.05 mol/L K₂FeO₄ (BC-Fe_0.05) showed optimal sulfadiazine (SDZ) removal performance in the peroxydisulfate (PDS) activation system with complete removal after 10 min, as it showed the highest adsorptive ability of SDZ. Moreover, BC-Fe_0.05 was able to remain stable after four cycles or 80 days of storage. Higher temperature, lower pH, and Cl^– were beneficial to SDZ removal efficiency, whereas CO₃^2- and HPO₄^2- had inhibitory effects. Non-radical species (¹O₂) and radical species (SO₄^·-, ·OH, and O₂^·-) both contributed to SDZ degradation, and ¹O₂ was the most important reactive oxygen species. Four degradation pathways were proposed based on ten identified intermediates. Potential eco-toxicity anal. by ECOSAR suggested that most intermediates were less toxic than their parent compound Overall, this study describes a green fabrication method for ZVI/BC with large SSA using K₂FeO₄ as the iron precursor. Generally, ZVI/BC with large SSA is an effective catalyst for activating persulfate to degrade antibiotics.

Name: Pyrimidin-2-amine, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., 109-12-6.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia