Category: 101257-82-3

Application of 101257-82-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 101257-82-3, name is 4-Amino-5-chloropyrimidine. A new synthetic method of this compound is introduced below.

55. 2-({3-Chloro-2-[(5-chloro-pyrimidin-4-ylamino)-methyl]-pyridin-4-yl}-methyl-amino)-ethanol The compound is obtained analogously to Example 2 from 2-[(3-chloro-2-chloromethyl-pyridin-4-yl)-methyl-amino]-ethanol (4.7 g, 20 mmol) and 4-amino-5-chloro-pyrimidin (2.6 g, 20 mmol). Yield: 2.64 g (29%). Mp.: 158-161 C.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,101257-82-3, 4-Amino-5-chloropyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; BYK Gulden Lomberg Chemische Fabrik GmbH; US6395732; (2002); B1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 101257-82-3, 4-Amino-5-chloropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C4H4ClN3, blongs to pyrimidines compound. Computed Properties of C4H4ClN3

59. (5-Chloro-pyrimidin-4-yl)-[4-(furan-2-ylmethylsulfanyl)-3-methyl-pyridin-2-ylmethyl]-amine The compound is obtained analogously to Example 40 from 4-amino-5-chloro-pyrimidine (1.34 g, 10.33 mmol) and 2-chloromethyl-4-(furan-2-ylmethylsulfanyl)-3-methyl-pyridine-hydrochloride (3.0 g, 10.33 mmol). The chromatography is done with toluene/ethyl acetate/methanol/conc. ammonia=6/3.5/0.5/0.01. The crude product is triturated with diethyl ether. Yield: 1.77 g (49%). Mp.: 169-170 C.

The synthetic route of 101257-82-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BYK Gulden Lomberg Chemische Fabrik GmbH; US6395732; (2002); B1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 101257-82-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 101257-82-3, name is 4-Amino-5-chloropyrimidine, molecular formula is C4H4ClN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

L. [4-(3-Chloropropylsulfanyl)-3-methylpyridin-2-ylmethyl]-(5-chloropyrimidin-4-yl)amine A solution of 2.7 g (20.85 mmol) of 4-amino-5-chloropyrimidine in 20 ml of dimethylformamide is added dropwise to a suspension of 0.75 g (18.25 mmol) of sodium hydride (60% strength in paraffin) in 5 ml of dimethylformamide. The mixture is stirred at room temperature for 20 minutes. A solution of 5 g (17.38 mmol) of 2-chloromethyl-4-(3-chloropropylsulfanyl)-3-methylpyridine in 5 ml of dimethylformamide is then added dropwise in the course of 30 minutes and the mixture is then stirred at room temperature for 4 hours. It is concentrated in a high vacuum and the residue is taken up in 150 ml of water and 100 ml of dichloromethane with vigorous stirring. The aqueous phase is extracted with 3*50 ml of dichloromethane. The organic extracts are dried over magnesium sulfate and concentrated. The residue is purified by chromatography on silica gel (eluent: toluene/ethyl acetate/methanol/conc. ammonia=6/3.5/0.5/0.05). The elude is concentrated and the residue is then digested with diethyl ether. After filtration and drying of the precipitate, 2.8 g (47%) of the title compound are obtained as a colorless solid, which is used without further purification.

According to the analysis of related databases, 101257-82-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BYK Gulden Lomberg Chemische Fabrik GmbH; US6395732; (2002); B1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 101257-82-3, name is 4-Amino-5-chloropyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 4-Amino-5-chloropyrimidine

AA. [4-(2-Chloro-ethoxy)-3-methyl-pyridin-2-ylmethyl]-(5-chloro-pyrimidin-4-yl)-amine The compound is obtained analogously to Example K starting with ethylenglycol and 4-chloro-2,3-dimethyl-pyridine-N-oxide and reaction of 4-amino-5-chloro-pyrimidine with 4-(2-chloro-ethoxy)-2-chloromethyl-3-methyl-pyridine in the last step.

With the rapid development of chemical substances, we look forward to future research findings about 101257-82-3.

Reference:
Patent; BYK Gulden Lomberg Chemische Fabrik GmbH; US6395732; (2002); B1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 101257-82-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 101257-82-3, name is 4-Amino-5-chloropyrimidine, molecular formula is C4H4ClN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

L. [4-(3-Chloropropylsulfanyl)-3-methylpyridin-2-ylmethyl]-(5-chloropyrimidin-4-yl)amine A solution of 2.7 g (20.85 mmol) of 4-amino-5-chloropyrimidine in 20 ml of dimethylformamide is added dropwise to a suspension of 0.75 g (18.25 mmol) of sodium hydride (60% strength in paraffin) in 5 ml of dimethylformamide. The mixture is stirred at room temperature for 20 minutes. A solution of 5 g (17.38 mmol) of 2-chloromethyl-4-(3-chloropropylsulfanyl)-3-methylpyridine in 5 ml of dimethylformamide is then added dropwise in the course of 30 minutes and the mixture is then stirred at room temperature for 4 hours. It is concentrated in a high vacuum and the residue is taken up in 150 ml of water and 100 ml of dichloromethane with vigorous stirring. The aqueous phase is extracted with 3*50 ml of dichloromethane. The organic extracts are dried over magnesium sulfate and concentrated. The residue is purified by chromatography on silica gel (eluent: toluene/ethyl acetate/methanol/conc. ammonia=6/3.5/0.5/0.05). The elude is concentrated and the residue is then digested with diethyl ether. After filtration and drying of the precipitate, 2.8 g (47%) of the title compound are obtained as a colorless solid, which is used without further purification.

According to the analysis of related databases, 101257-82-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BYK Gulden Lomberg Chemische Fabrik GmbH; US6395732; (2002); B1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia