Category: 1004-39-3

Synthetic Route of 1004-39-3 ,Some common heterocyclic compound, 1004-39-3, molecular formula is C4H6N4S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

EB1 Schiff base was synthesized by reaction of 30mL of ethanol hot solution (60 C) of bisaldehyde (2,2?-(ethane-1,2-diylbis(oxy))dibenzaldehyde) (1 g, 3.7¡Á10-3mole) and 30 mL hot ethanol solution (60 C) of (hydrazine carbothioamide) (0.674 g, 7.4¡Á10-3mole) in ratio (1:2). In preparation of L1 Schiff base 30 mL of ethanol hot solution (60 C) of bisaldehyde (2,2?-(ethane-1,2-diylbis(oxy))dibenzaldehyde) (1 g, 3.7¡Á10-3mole) was mixed with 30 mL hot ethanol solution (60 C) (4,6-diaminopyrimidine-2-thiol) (0.525 g, 3.6¡Á10-3mole) in ratio (1:1). Then sulfuric acid was added to eliminate water through condensation, and then the reaction mixture was left under reflux for 2 h. The formed solid Schiff?s bases were separated by filtration and purified by crystallization from ethanol. This preparation can be summarized in the following Scheme 1.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1004-39-3, its application will become more common.

Reference:
Article; Zayed, Ehab M.; Zayed; El-Desawy; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy; vol. 134; (2015); p. 155 – 164;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 1004-39-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1004-39-3, name is 4,6-Diaminopyrimidine-2-thiol, molecular formula is C4H6N4S, molecular weight is 142.18, as common compound, the synthetic route is as follows.

General procedure: DBU (0.33 ml, 2.2 mmol) was added dropwise at roomtemperature to a stirred suspension of the respective thiol2a-n (2.2 mmol) in anhydrous MeCN (4 ml). The obtainedmixture was stirred for 15 min and then furoxan 1d (0.34 g,1.0 mmol) was added. The reaction mixture was furtherstirred for 48-120 h until complete conversion of thestarting furoxan 1d (control by TLC, eluent CHCl3). Thereaction mixture was then diluted with H2O (20 ml). The precipitate formed was filtered off, carefully washed withwater, 0.75 N NaOH, then again with water, acetonitrile(~1 ml), and air-dried.

The chemical industry reduces the impact on the environment during synthesis 1004-39-3, I believe this compound will play a more active role in future production and life.

Reference:
Article; Fershtat, Leonid L.; Epishina, Margarita A.; Kulikov, Alexander S.; Struchkova, Marina I.; Makhova, Nina N.; Chemistry of Heterocyclic Compounds; vol. 51; 2; (2015); p. 176 – 186; Khim. Geterotsikl. Soedin.; vol. 51; 2; (2015); p. 176 – 186,11;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1004-39-3, name is 4,6-Diaminopyrimidine-2-thiol, molecular formula is C4H6N4S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. name: 4,6-Diaminopyrimidine-2-thiol

Potassium hydroxide (88.8 g, 1.58 mol) and 4,6-diamino-2-mercaptopyrimidine (45.0 g, 316 mmol) were sequentially added to 230 ml of water and heated at 85 C. for 2 h.Add 220 ml of methanol, 1-bromo-3,3,3-trifluoropropane (280 g, 1.58 mol) and KI(2.63 g, 15.8 mmol), continued stirring at 60 C for 24 h. The reaction solution was concentrated under reduced pressure.After cooling to room temperature, the filter cake was dried to obtain 71.6 g of a yellow solid with a yield of 95%.

With the rapid development of chemical substances, we look forward to future research findings about 1004-39-3.

Reference:
Patent; Shanghai Pharmaceutical Industry Institute; China Pharmaceutical Industry Zongyuan; Li Jianqi; Lu Kuanying; Ma Zhilong; Jin Xunqi; Zhou Chao; (21 pag.)CN107973832; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 1004-39-3, Adding some certain compound to certain chemical reactions, such as: 1004-39-3, name is 4,6-Diaminopyrimidine-2-thiol,molecular formula is C4H6N4S, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1004-39-3.

General procedure: DBU (0.5 mmol, 0.08 g) was added dropwise at room temperature to a magnetically stirred suspension of appropriate thiol 2 (0.5 mmol) in 1 ml of MeCN. The mixture was stirred for 10 min and then appropriate nitrofuroxan 1 (0.5 mmol) was added. The mixture was stirred for 0.5-10 h until initial compound 1 disappeared (TLC monitoring, eluent – CHCl3). Next, H2O (7 ml) was added and the reaction mixture was acidified with 1 n HCl until pH 1. The produced solid was filtered off, washed with water and the MeCN minimal volume (~1 ml), and air-dried. Compounds 3i and 4 were prepared as a mixture. The mixture was treated with 2 ml of DMSO at 60 C for 30 min; the undissolved solid was filtered off, water-washed and air-dried to afford disulfide 4. The filtrate was diluted with water and the solid was filtered off, water-washed and air-dried to afford compound 3i.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1004-39-3, 4,6-Diaminopyrimidine-2-thiol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Fershtat, Leonid L.; Epishina, Margarita A.; Kulikov, Alexander S.; Makhova, Nina N.; Mendeleev Communications; vol. 25; 1; (2015); p. 36 – 38;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 1004-39-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1004-39-3, name is 4,6-Diaminopyrimidine-2-thiol, molecular formula is C4H6N4S, molecular weight is 142.18, as common compound, the synthetic route is as follows.

3.79 g (10 mmol) of pleuromutilin were added to a 250 mL flask.2.1 g (11 mmol) of p-toluenesulfonyl chloride was added to 60 mL of dichloromethane, and the temperature was raised to 45C.A 2.5 ml NaOH solution having a concentration of 0.01 mol/ml was slowly added dropwise with stirring, and a large amount of white substance was generated after the reaction for 40 minutes.At room temperature, 1.44 g of 4,6-diamino-2-mercaptopyrimidine and 20 mL of methanol were added and the reaction was stirred at room temperature for 36 h.After the reaction, the solvent was evaporated under reduced pressure. The crude product was extracted with 30 mL of ethyl acetate and 10 mL of solvent.Take three times, combine the organic phase,30 mL of a saturated NaHCO 3 solution was added and the mixture was filtered to obtain the compound of Formula I (4.77 g, yield 95%).

The chemical industry reduces the impact on the environment during synthesis 1004-39-3, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Chinese Academy Of Agricultural Sciences Lanzhou Husbandry And Veterinary Drugs Institute; Shang Ruofeng; Yi Yunpeng; Liu Yu; Ai Xin; Yang Zhen; Liang Jianping; (13 pag.)CN105622524; (2018); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 1004-39-3 ,Some common heterocyclic compound, 1004-39-3, molecular formula is C4H6N4S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

PREPARATION 6 Synthesis of 4,6-diaminopyrimidine 167.78 g of 2-mercapto-4,6-diaminopyrimidine was dissolved in 1007 ml of 1.5N-aqueous sodium hydroxide solution, and the reaction solution was cooled down to 0 to 4 C. To this reaction solution was slowly added dropwise 267.55 g of 30% aqueous hydrogen peroxide solution. After the addition is completed, 170 ml of acetic acid was slowly added dropwise to the reaction solution to precipitate the solid product which was then filtered, washed successively with 200 ml of distilled water, 200 ml of methanol and 400 ml of diethylether and dried to obtain 185.56 g of the solid product as a white powder. The solid product thus obtained was slowly added to 1 L concentrated hydrochloric acid which was cooled to 0 C. to 4 C. The reaction solution was stirred for one hour at the same temperature, warmed to room temperature and then stirred for further 8 hours. The solid product produced during the reaction was filtered, washed with 1 L of acetone and 1 L of diethylether and then dried to obtain 109.13 g of the title compound in the form of hydrochloride salt. 109.13 g of the solid thus obtained was suspended in 400 ml of distilled water, and 200 ml of 15% aqueous sodium hydroxide solution was then added thereto. The mixture was stirred at room temperature for one hour and filtered. The filtered solid product was washed with 400 ml of ethanol and then dried to obtain 100.7 g of the title compound as a white powder. NMR (delta, DMSO-d6): 5.34(s, 1H), 6.01(s, 4H), 7.78(s, 1H)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1004-39-3, its application will become more common.

Reference:
Patent; Lucky, Ltd.; US5541175; (1996); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia