《Pyrimidine reactions. XVI. Thermal rearrangement of substituted 2- and 4-alkoxyprimidines》 was published in Australian Journal of Chemistry in 1968. These research results belong to Brown, Desmond J.; Lee, Tzoong-Chyh. Category: pyrimidines The article mentions the following:
Thermal rearrangement of methyl, bromo, and nitro derivatives of 2- and 4- alkoxypyrimidines produced their N-alkyl isomers, identified by proton magnetic resonance spectral comparison with synthetic specimens of unambiguous or proven structure. The rates for such isomerizations were measured by changes in uv spectra. The C-methyl derivatives rearranged more slowly than the parent alkoxypyrimidines, but the bromo, and especially the nitro derivatives did so much more quickly. Among the derivatives of each methoxypyrimidine, the rate of rearrangement increased as the basic pKa value fell and as the methoxyl protons moved downfield, thus affording a qual. correlation with properties reflecting the electronic effect of each substituent. 32 references. The experimental process involved the reaction of 2-Methoxy-4-methylpyrimidine(cas: 14001-60-6Category: pyrimidines)
2-Methoxy-4-methylpyrimidine(cas: 14001-60-6) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Category: pyrimidines
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia