《Pyrimidine reactions. XIV. The butylaminolysis of substituted methoxy- and methylthiopyrimidines》 was published in Australian Journal of Chemistry in 1966. These research results belong to Brown, Desmond J.; Foster, Roy V.. COA of Formula: C6H8N2O The article mentions the following:
cf. CA 65, 15374e Aminolyses of 2- and 4-methoxy (or methylthio) pyrimidines bearing C-methyl, CC’-dimethyl, 5-bromo, or 5-intro substituents have proved of value, in the absence of added solvent, for preparing the corresponding n- and tert-butylamino-pyrimidines. When these displacements are followed spectro-metrically, the apparent 1st-order rate constants indicate mild deactivation by addnl. methyl substituents, moderate activation by a bromo substituent, and profound activation by a nitro substituent. Ionization constants and uv spectra of relevant pyrimidines are recorded. 31 references. In addition to this study using 2-Methoxy-4-methylpyrimidine, there are many other studies that have used 2-Methoxy-4-methylpyrimidine(cas: 14001-60-6COA of Formula: C6H8N2O) was used in this study.
2-Methoxy-4-methylpyrimidine(cas: 14001-60-6) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.COA of Formula: C6H8N2O
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia