The systematic study of pyrimidines began in 1884 with Pinner, who synthesized derivatives by condensing ethyl acetoacetate with amidines. Pinner first proposed the name “pyrimidin” in 1885. 2927-71-1, formula is C4HCl2FN2, Name is 2,4-Dichloro-5-fluoropyrimidine. The parent compound was first prepared by Gabriel and Colman in 1900, by conversion of barbituric acid to 2,4,6-trichloropyrimidine followed by reduction using zinc dust in hot water. Recommanded Product: 2,4-Dichloro-5-fluoropyrimidine.
Bandarage, Upul K.;Clark, Michael P.;Perola, Emanuele;Gao, Huai;Jacobs, Marc D.;Tsai, Alice;Gillespie, Jeffery;Kennedy, Joseph M.;Maltais, Francois;Ledeboer, Mark W.;Davies, Ioana;Gu, Wenxin;Byrn, Randal A.;Nti Addae, Kwame;Bennett, Hamilton;Leeman, Joshua R.;Jones, Steven M.;O’Brien, Colleen;Memmott, Christine;Bennani, Youssef;Charifson, Paul S. research published 《 Novel 2-Substituted 7-Azaindole and 7-Azaindazole Analogues as Potential Antiviral Agents for the Treatment of Influenza》, the research content is summarized as follows. JNJ-63623872 (2) is a first-in-class, orally bioavailable compound that offers significant potential for the treatment of pandemic and seasonal influenza. Early lead optimization efforts in our 7-azaindole series focused on 1,3-diaminocyclohexyl amide and urea substitutions on the pyrimidine-7-azaindole motif. In this work, we explored two strategies to eliminate observed aldehyde oxidase (AO)-mediated metabolism at the 2-position of these 7-azaindole analogs. Substitution at the 2-position of the azaindole ring generated somewhat less potent analogs, but reduced AO-mediated metabolism Incorporation of a ring nitrogen generated 7-azaindazole analogs that were equipotent to the parent 2-H-7-azaindole, but surprisingly, did not appear to improve AO-mediated metabolism Overall, we identified multiple 2-substituted 7-azaindole analogs with enhanced AO stability and we present data for one such compound (12) that demonstrate a favorable oral pharmacokinetic profile in rodents. These analogs have the potential to be further developed as anti-influenza agents for the treatment of influenza.
Recommanded Product: 2,4-Dichloro-5-fluoropyrimidine, 2,4-Dichloro-5-fluoropyrimidine is a useful research compound. Its molecular formula is C4HCl2FN2 and its molecular weight is 166.97 g/mol. The purity is usually 95%.
2,4-Dichloro-5-fluoropyrimidine is an aromatic hydrocarbon that has been shown to inhibit the growth of mouse tumor cells in vitro. It also inhibits the production of amines by reacting with industrial chemicals and sodium carbonate. This compound has potent inhibitory activity against autoimmune diseases and cytotoxic potency on mcf-7 cells. Furthermore, 2,4-Dichloro-5-fluoropyrimidine has been shown to have a chlorinating effect on cancer cells., 2927-71-1.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia