The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. 1722-12-9, formula is C4H3ClN2, Name is 2-Chloropyrimidine. It is also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Computed Properties of 1722-12-9.
Ban, Yong-Liang;You, Long;Wang, Tao;Wu, Li-Zhu;Liu, Qiang research published 《 Metallaphotoredox Dearomatization of Indoles by a Benzamide-Empowered [4 + 2] Annulation: Facile Access to Indolo[2,3-c]isoquinolin-5-ones》, the research content is summarized as follows. Herein, a metallaphotoredox catalysis protocol enabling the efficient dearomatization of indoles I (R = quinolin-8-yl, (tert-butoxy)carbonyl; R1 = H, Me, OMe, hydroxymethyl, (acetyloxy)methyl; R2 = H, F, 2-oxocyclohexyl, morpholin-4-yl, etc.; R3 = H, Me; R4 = H, Me) utilizing readily available N-quinolyl benzamides II (R5 = Ph, thiophen-2-yl, 2H-1,3-benzodioxol-5-yl, etc.) under environmentally benign reaction conditions was reported. This reaction allows regioselective C-2 and C-3 dual functionalization of indoles and provides a mild, straightforward, and high atom- and step-economical approach to produce a diverse array of indolo[2,3-c]isoquinolin-5-ones e.g., III by merging cobalt catalysis with photocatalysis. The practicality and effectiveness of this synergistic protocol were illustrated by a gram-scale experiment Preliminary mechanistic studies indicate that a single-electron transfer process is involved during the catalytic cycle. In addition, a catalytically competent organometallic Co(bzac)3 has been identified through X-ray crystallog., 1H NMR, 13C NMR, and ESI-HRMS.
Computed Properties of 1722-12-9, 2-Chloropyrimidine is a monochlorinated pyrimidine with plant growth regulating activity. Chloropyrimidine is a useful reagent in the preparation of antivirals and other biologically active compounds.
2-Chloropyrimidine undergoes cobalt-catalyzed cross-coupling reaction with aryl halides.
2-Chloropyrimidine is a molecule that can be synthesized by the oxidation of pyrimidine with hydrogen peroxide and hydrochloric acid. The reaction proceeds through an electrochemical process in which the oxidation catalyst is a platinum electrode. This reaction is catalyzed by the nucleophilic attack of malonic acid on the chloropyrimidine at the methylene group. This efficient method for making 2-chloropyrimidine has been applied to synthesize aryl halides, including phenyl chloropyrimidine and pyridyl chloropyrimidine, from their corresponding chloride and bromide precursors. The fluorescence properties of 2-chloropyrimidine have been studied in coordination chemistry, where it forms complexes with metal ions such as Mn2+. In this study, it was found that adsorption mechanisms are dependent on molecular size, charge density, kinetic energy, and adsorbent surface area., 1722-12-9.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia