Application of N-(4-Fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1421372-94-2, its application will become more common.

Reference of 1421372-94-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1421372-94-2 as follows.

2 g of N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine was added to the reaction flask. 20mLDMA,After thorough stirring, 4.5 mL of dimethylamine and 1 g of DIEA were continuously added.After all the materials are stirred uniformly, the temperature is raised to 90 C, and the reaction is heated and refluxed for 2 to 3 hours.The spot plate is monitored until there is no raw material point, that is, the reaction is completed. Drop to room temperature, suction filtration,Washed, blast dried to constant weight, red solid, dry weight 2.40g

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1421372-94-2, its application will become more common.

Reference:
Patent; Jiangnan University; Hui Renjie; Feng Jing; Miao Lili; Zeng Shuai; (7 pag.)CN109438422; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia