Related Products of 123240-66-4, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 123240-66-4 as follows.
a) 4-Chloro-6-[3-(diethoxyphosphorylmethoxy)proooxvamino]-5-formamidopyrimidine A mixture of diethyl 3-aminooxypropoxymethylphosphonate (1.0 g, 4.15 mmol), 4,6-dichloro-5-formamidopyrimidine (0.80 g, 4.15 mmol) and diisopropylethylamine (2.16 ml, 12.45 mmol) in diglyme (25 ml) was heated at 100 C. for 2 h. The solvent was then removed in vacuo and the residue chromatographed in chloroform/methanol (50:1) to give 4-chloro-6-[3-(diethoxyphosphorylmethoxy)propoxyamino]-5-formamidopyrimidine (1.lg, 67%) as a brown oil; numax (film) 1600, 1570, 1220, 1030 cm-1; deltaH [(CD3)2 SO] 1.23(6H, t, J7.2 Hz, (CH3 CH2 O)2), 1.85(2H, m, CH2 CH2 CH2), 3.63(2H, t, J6 Hz, CH2 OCH2 P), 3.79(2H, d, J8.3 Hz, CH2 P), 3.94(2H, t, J6.1Hz, CH2 ON), 4.04(4 H, m, (CH3 CH2 O)2), 8.15(1H, s, H-2), 9.50(1H, br s, D2 O exchangeable, NH), 10.50-12.00(1H, br s, NH); Found: C, 39.37; H, 5.69; N, 13.82%; M+ 396.0963; C13 H22 ClN4 O6 P requires: C, 39.35; H, 5.59; N, 14.12%; M+ 396.0966.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,123240-66-4, its application will become more common.
Reference:
Patent; Beecham Group P.l.c.; US5055458; (1991); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia