Analyzing the synthesis route of Application In Synthesis of 4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine

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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 42754-96-1, name is 4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine

To a solution of cyclopropylmethanol (1.908 g, 26.5 mmol) in THF (200mL) was addedsodium hydride (3.17 g, 79 mmol) in an ice bath. After stirred for 30 mm, 4,6-dichloro-1H- pyrazolo[3,4-d]pyrimidine (5 g, 26.5 mmol). The reaction mixture was gradually allowed to room temperature and stirred overnight. Then the mixture was diluted with water (80 mL), concentrated to remove solvent and diluted with ethyl acetate (220 mL). The organic layerwas washed with water (80 mLx 2), dried over Na2SO4, filtered and concentrated. The crude(5 g, 84% yield) was directly used into next step.LCMS: 225[M+H]. tR2.9l8 (LCMS condition 1)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 42754-96-1, 4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; GLAXOSMITHKLINE (CHINA) R&D COMPANY LIMITED; DING, Xiao; LIU, Qian; LONG, Kai; SANG, Yingxia; STASI, Luigi Piero; WAN, Zehong; XU, Qiongfeng; EDGE, Colin Michael; WO2015/113451; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia