Application of 1004-39-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1004-39-3, name is 4,6-Diaminopyrimidine-2-thiol, molecular formula is C4H6N4S, molecular weight is 142.18, as common compound, the synthetic route is as follows.
3.79 g (10 mmol) of pleuromutilin were added to a 250 mL flask.2.1 g (11 mmol) of p-toluenesulfonyl chloride was added to 60 mL of dichloromethane, and the temperature was raised to 45C.A 2.5 ml NaOH solution having a concentration of 0.01 mol/ml was slowly added dropwise with stirring, and a large amount of white substance was generated after the reaction for 40 minutes.At room temperature, 1.44 g of 4,6-diamino-2-mercaptopyrimidine and 20 mL of methanol were added and the reaction was stirred at room temperature for 36 h.After the reaction, the solvent was evaporated under reduced pressure. The crude product was extracted with 30 mL of ethyl acetate and 10 mL of solvent.Take three times, combine the organic phase,30 mL of a saturated NaHCO 3 solution was added and the mixture was filtered to obtain the compound of Formula I (4.77 g, yield 95%).
The chemical industry reduces the impact on the environment during synthesis 1004-39-3, I believe this compound will play a more active role in future production and life.
Reference:
Patent; Chinese Academy Of Agricultural Sciences Lanzhou Husbandry And Veterinary Drugs Institute; Shang Ruofeng; Yi Yunpeng; Liu Yu; Ai Xin; Yang Zhen; Liang Jianping; (13 pag.)CN105622524; (2018); B;,
Pyrimidine | C4H4N2 – PubChem,
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