Related Products of 199678-12-1, Adding some certain compound to certain chemical reactions, such as: 199678-12-1, name is 4-Pyrimidin-2-yl-benzoic acid,molecular formula is C11H8N2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 199678-12-1.
Under an argon atmosphere, diethyl cyanophosphonate (0.27 mL, 1.80 mmol) and triethylamine (0.52 mL, 3.75 mmol) were added to a solution of compound 12 (303 mg, 1.50 mmol) and 4-pyrimidin-2-ylbenzoic acid (300 mg, 1.50 mmol) in dehydrated N,N-dimethylformamide (10 mL) at 0 C and the mixture was left to stand overnight. The reaction mixture was poured into saturated aqueous sodium hydrocarbonate and the whole was extracted with ethyl acetate. The extract was washed with brine, dried over anhydrous magnesium sulfate and concentrated. The residue was purified by silica gel column chromatography (eluent; n-hexane:ethyl acetate 1:1 v/v) to afford 364 mg (70%) of the title compoundas a white solid. 1H NMR (400 MHz, CDCl3) delta 8.83 (d, J = 4.8 Hz, 2H), 8.50 (d, J = 8.4 Hz, 2H), 7.88 (d, J = 8.4 Hz, 2H), 7.36(dd, J = 7.2, 1.6 Hz, 1H), 7.27 (ddd, J = 8.0, 8.0, 1.8 Hz, 1H), 7.23 (t, J = 4.8 Hz, 1H), 6.94 (ddd, J 7.6, 7.6, 0.8 Hz, 1H), 6.90 (d, J = 8.4 Hz,1H), 6.80 (t, J = 5.8 Hz, 1H), 4.69 (d, J = 5.6 Hz, 2H), 4.01 (t, J = 6.6 Hz,2H), 1.91 – 1.82 (m, 2H), 1.07 (t, J = 7.4 Hz, 3H).
According to the analysis of related databases, 199678-12-1, the application of this compound in the production field has become more and more popular.
Reference:
Article; Ohashi, Masao; Gamo, Kanae; Tanaka, Yuta; Waki, Minoru; Beniyama, Yoko; Matsuno, Kenji; Wada, Jun; Tenta, Masafumi; Eguchi, Jun; Makishima, Makoto; Matsuura, Nobuyasu; Oyama, Takuji; Miyachi, Hiroyuki; European Journal of Medicinal Chemistry; vol. 90; (2015); p. 53 – 67;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia