Electric Literature of 17759-30-7 ,Some common heterocyclic compound, 17759-30-7, molecular formula is C7H11N3OS, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a solution of Example Cl (10 g, 56 mmol) in anhydrous THF (120 mL) was added thionyl chloride (10.4 mL, 140 mmol) slowly at 00C. The resulting mixture was stirred at 800C for 4 hours. The solvent was removed under reduced pressure to give 5-(chIoromethyl)-N- methyl-2-(methylthio)pyrimidin-4-amine (11.5 g, >I00% yield), which was used directly in the next step.; To a solution of Example Cl (2 g, 11 mmol) in anhydrous THF (120 raL) was added thionyl chloride (1.74 mL, 23 mmol) slowly at 00C. The resulting mixture was stirred at 80 C for 4 hours. The solvent was removed under reduced pressure to give 5-(chloromethyl)- N-methyl-2-(methylthio)pyrimidin-4-amine (2.1 g) which was used directly in the next step.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 17759-30-7, (4-(Methylamino)-2-(methylthio)pyrimidin-5-yl)methanol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; DECIPHERA PHARMACEUTICALS, LLC; WO2008/33999; (2008); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia