The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1032452-86-0, name is 3-(2-Chloropyrimidin-4-yl)-1-methyl-1H-indole. This compound has unique chemical properties. The synthetic route is as follows. name: 3-(2-Chloropyrimidin-4-yl)-1-methyl-1H-indole
N-(5-amino-4-methoxy-2-(trifluoromethyl)phenyl)acetamide (496 mg, 2.0 mmol),3-(2-chloropyrimidin-4-yl)-1-methyl-1H-indole (704 mg, 4.0 mmol) was dissolved in 2-pentanol (10 mL),Then p-toluenesulfonic acid monohydrate (688 mg, 4.0 mmol) was added.The reaction was stirred at 130 C for 4 hours.After the reaction is over,Cool to room temperatureSaturated sodium bicarbonate (20 mL) was added to the reaction solution.Extract with dichloromethane (100 mL x 3).Combine the organic phase,The organic phase was washed with saturated brine (100 mL).Drying with anhydrous sodium sulfateConcentrate under reduced pressure,The crude product was isolated and purified by silica gel column chromatography (eluent: petroleum ether:Ethyl acetate = 2:1) gave a yellow solid (113 mg, yield: 12.4%).
With the rapid development of chemical substances, we look forward to future research findings about 1032452-86-0.
Reference:
Patent; Tianjin Binjiang Pharmaceutical Research And Development Co., Ltd.; Tian Hongqi; Huang Gongchao; Cheng Ying; (48 pag.)CN107793413; (2018); A;,
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