Adding a certain compound to certain chemical reactions, such as: 14394-70-8, 2-Chloro-5-methylpyrimidin-4-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 14394-70-8, blongs to pyrimidines compound. Formula: C5H6ClN3
[0293] A mixture of l-bromo-3,5-dimethoxybenzene (436 mg, 2.01 mmol), 2-chloro~5- methyl-pyrimidin-4-ylamine (287 mg, 2.00 mmol), Pd(OAc)2 (44 mg, 0.20 mmol), Xantphos (237 mg, 0.41 mmol) and potassium fe/t-butoxide (448 mg, 3.99 mmol) in dioxane (15 mL) and DMF (5 mL) was microwaved at 160 C for 20 min. The reaction mixture was cooled to room temperature and filtered rinsing with DCM and methanol. The filtrate was concentrated and purified using gradient flash chromatography (0-100% ethyl acetate in hexanes) to afford the title compound as a yellow solid (182 mg, 33%).[0294] 1H NMR (500 MHz, DMSO-d6): delta 2.17 (s, 3H), 3.74 (s, 6H), 6.27 (t, J= 2.2 Hz, IH), 6.99 (d, J=2.2 Hz, 2H), 8.06 (s, IH), 8.71 (s, IH). MS (ES+): m/z 280 (M+H)+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,14394-70-8, its application will become more common.
Reference:
Patent; TARGEGEN, INC.; WO2007/53452; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia