Analyzing the synthesis route of 2-Amino-4-chloro-6-methylpyrimidine-5-carbonitrile

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 99586-66-0, 2-Amino-4-chloro-6-methylpyrimidine-5-carbonitrile, other downstream synthetic routes, hurry up and to see.

Reference of 99586-66-0 ,Some common heterocyclic compound, 99586-66-0, molecular formula is C6H5ClN4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: d) At rt, a solution of intermediate Xl (1 eq.) and an aryl halogenide VIII (1 to 2.5 eq.) in alcohol (nBuOH or EtOH, 0.08M to 0.1M) was treated with DIPEA (2 to Seq.) and irridiated in a microwave reactor or heated in an oil bath at 120-160C for 0.5 h to 6 d. Purification of intermediates and final products IX was carried out by flash chromatography,HPLCorSFC.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 99586-66-0, 2-Amino-4-chloro-6-methylpyrimidine-5-carbonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NOVARTIS AG; DU, Zhenxing; HINTERMANN, Samuel; HURTH, Konstanze; JACQUIER, Sebastien; LEHMANN, Hansjoerg; MOEBITZ, Henrik; SOLDERMANN, Nicolas; STOJANOVIC, Aleksandar; WO2015/10641; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia