Related Products of 138274-14-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 138274-14-3, name is 5-(Benzyloxy)-2-chloropyrimidine, molecular formula is C11H9ClN2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To 5-benzyloxy-2-chloro-pyrimidine 34b (0.20 g, 0.91 mmol) of N-methylpyrrolidone (5 mL)Potassium fluoride (0.17 g, 2.9 mmol) was added to the solution.Thiomorpholine dioxide (0.13 g, 0.91 mmol). After the addition, the reaction solution was heated to 140 C for 23 hours.The heating was stopped, and after the reaction solution was cooled to room temperature, dichloromethane (30 mL) and water (10 mL) were added and stirred for 10 minutes.The lower organic phase was separated, the aqueous phase was extracted with dichloromethane (10 mL¡Á3), and the combined organic phases were washed with saturated sodium chloride solution (10 mL).Dry over anhydrous sodium sulfate, concentrate by suction filtration, and the residue obtained was purified by silica gel column chromatography[Petroleum ether / ethyl acetate (v / v) = 5 / 1] purified to give the title compound50a (60 mg, 21% yield) as a pale yellow solid.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 138274-14-3, 5-(Benzyloxy)-2-chloropyrimidine.
Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Gu Zheng; Li Jianhao; Li Zheng; Wang Weihua; Tan Haoxiong; Wang Xuli; Cui Yunzeng; Xie Zeqiang; Zhang Yingjun; (101 pag.)CN109251166; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia