Application of 13566-48-8, Adding some certain compound to certain chemical reactions, such as: 13566-48-8, name is 2-Methyl-4,6-dimethoxypyrimidine,molecular formula is C7H10N2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 13566-48-8.
4,6-Dimethoxy-2-methylpyrimidine (5 g, 32.4 mmol) was dissolved in 443 carbon tetrachloride (54.1 mL) and 61 N-bromosuccinimide (5.77 g, 32.4 mmol) and 444 azobisisobutyronitrile (0.266 g, 1.622 mmol) were added sequentially to the pressure tube, which was sealed and heated to 80 C. for 4 hours and 100 C. for 16 hours. The reaction vessel was cooled to ambient temperature, concentrated in vacuo, and the resulting crude material was purified via flash chromatography, eluting with 0:100 to 25:75 ethyl acetate:heptanes on a 120 g silica gel column over 20 minutes to provide the 445 title compound. 1H NMR (400 MHz, CDCl3) delta ppm 5.92 (s, 1H), 4.39 (s, 2H), 3.95 (s, 6H); MS (ESI+) m/z 235.0 (M+H)+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 13566-48-8, 2-Methyl-4,6-dimethoxypyrimidine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; AbbVie S.a.r.l.; Galapagos NV; Altenbach, Robert J.; Bogdan, Andrew; Desroy, Nicolas; Gfesser, Gregory A.; Greszler, Stephen N.; Koenig, John R.; Kym, Philip R.; Liu, Bo; Scanio, Marc J.; Searle, Xenia; Wang, Xueqing; Yeung, Ming C.; Zhao, Gang; (247 pag.)US2018/99932; (2018); A1;,
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