Synthetic Route of 1119280-68-0, Adding some certain compound to certain chemical reactions, such as: 1119280-68-0, name is 2-Chlorothieno[3,2-d]pyrimidine,molecular formula is C6H3ClN2S, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1119280-68-0.
To a solution of 2-chlorothieno[3,2-d]pyrimidine (150mg, 0.87mmol) and 4- morpholinoaniline (188mg, 1.05mmol) in NMP (5mL) was added diisopropylethylamine (337muL, 1.93mmol). The reaction was heated at 25O 0C in a microwave reactor for 20min, then diluted with EtOAc and 5%aq. citric acid. The aqueous layer was extracted twice further with EtOAc and the combined organic fractions washed with sat. aq. NaHCO3, dried (Na2SO4) filtered and concentrated to afford the crude product. Purification by silica gel chromatography using 30-70% EtOAc/DCM as eluent then afforded the product as an orange gum. Trituration with EtOAc three times and collection of the fine solid afforded compound 7 as a dark yellow solid (26mg, 10%).
According to the analysis of related databases, 1119280-68-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; CYTOPIA RESEARCH PTY LTD; WO2009/62258; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia