Reference of 4318-56-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 4318-56-3, name is 6-Chloro-3-methylpyrimidine-2,4(1H,3H)-dione. This compound has unique chemical properties. The synthetic route is as follows.
Step 1 : 6-Chloro-3-methylpyrimidine-2,4 (l/7,3/7)-dione (43 g, 267 mmol), (1192) K2C03 (92.1 g, 667 mmol) and PMB-C1 (1.4 g, 28.0 mmol) were taken up in DMF (500 mL). The reaction mixture was stirred at 50 C for 16 hours. The mixture was partitioned between H20 (1000 mL) and EtOAc (1500 mL) and the aqueous phase was extracted with EtOAc (800 mL x 2). The combined organics were washed with brine (500 mL x 2), dried over anhydrous Na2S04, filtered, and concentrated under reduced pressure to give a residue.Trituration with petroleum ether/EtOAc (10 : 1) resulted in the formation of a precipitate which was collected by filtration, washed with petroleum ether/EtOAc (10 : l, 100 mL), and dried to give 6-chloro-l-(4-methoxybenzyl)-3-methylpyrimidine-2, 4(1/7, 3/7)-dione (50.0 g, 66.7% yield) as a white solid.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 4318-56-3, 6-Chloro-3-methylpyrimidine-2,4(1H,3H)-dione.
Reference:
Patent; RELAY THERAPEUTICS, INC.; D.E. SHAW RESEARCH, LLC; WALTERS, W., Patrick; LESCARBEAU, Andre; KELLEY, Elizabeth, H.; SHORTSLEEVES, Kelley, C.; TAYLOR, Alexander, M.; PIERCE, Levi Charles, Thomas; MURCKO, Mark, Andrew; GIORDANETTO, Fabrizio; GREISMAN, Jack, Benjamin; MARAGAKIS, Paul; BHAT, Sathesh; KONZE, Kyle; DAHLGREN, Markus, Kristofer; THERRIEN, Eric; (0 pag.)WO2019/165073; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
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