A new synthetic route of 7399-93-1

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 7399-93-1, Methyl 6-oxo-3,6-dihydropyrimidine-4-carboxylate, other downstream synthetic routes, hurry up and to see.

Reference of 7399-93-1 ,Some common heterocyclic compound, 7399-93-1, molecular formula is C6H6N2O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 96-Oxo-1,6-dihydropyrimidine-4-carbohydrazide; The subtitle compound of step 9A was stirred as a slurry in anhydrous methanol and hydrazine monohydrate (3 eq.) was added. The solid first dissolved but within 5 minutes the product started to precipitate. More methanol was added and the slurry was stirred at it overnight, filtered, washed with methanol, and dried in vacuo to give the title product (91%).1H NMR (400 MHz, DMSO-d6): delta 12.36 (broad s, 1H), 9.88 (s, 1H), 8.23 (s, 1H), 6.67 (s, 1H), 4.67 (s, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 7399-93-1, Methyl 6-oxo-3,6-dihydropyrimidine-4-carboxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; AstraZeneca AB; US2009/111821; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia