A new synthetic route of 2-Chloro-N-isopropyl-5-nitropyrimidin-4-amine

Statistics shows that 890094-38-9 is playing an increasingly important role. we look forward to future research findings about 2-Chloro-N-isopropyl-5-nitropyrimidin-4-amine.

Reference of 890094-38-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.890094-38-9, name is 2-Chloro-N-isopropyl-5-nitropyrimidin-4-amine, molecular formula is C7H9ClN4O2, molecular weight is 216.63, as common compound, the synthetic route is as follows.

4-morpholinophenylamine(3.6g) was added to a solution of Compound 2-3(4.3g) in n-butanol(150ml). The mixture was reacted at 90C for 4 hours, cooled to room temperature, filtered, washed and dried to obtain a red solid(5.3g) in a yield of 74.7%. MS m/z(ESI): 359[M+H]+.

Statistics shows that 890094-38-9 is playing an increasingly important role. we look forward to future research findings about 2-Chloro-N-isopropyl-5-nitropyrimidin-4-amine.

Reference:
Patent; Si Chuan University; CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.; YANG, Shengyong; WEI, Yuquan; EP2578584; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia