Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1211443-61-6, name is 2-Chloro-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 1211443-61-6
50 mL two neck-flask was charged with 2-chloro-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d] pyrimidine-6-carboxamide(835 mg, 2.85 mmol), 2-amino-5-(4-(tertbutoxycarbonyl)piperazin-1-yl) pyridine 1-oxide (840 mg,2.85 mmol), Palladium diacetate(16 mg, 0.071 mmol),BINAP (89 mg, 0.143 mmol), cesium carbonate (1.39 g,4.3 mmol) and 1,4-dioxane (20 mL) and stirred at 100 Cunder inert atmosphere overnihgt. The reaction mixture wasconcentrated and purified by column chromatography toafford the title compound 7 (1.1 g, 68%) as tan solid. 1HNMR (400 MHz, Chloroform-d) delta 9.63 (s, 1H), 8.73 (d, J= 1.3 Hz, 1H), 8.65 (d, J = 9.4 Hz, 1H), 7.95 (d, J = 2.3 Hz,1H), 7.05 (dd, J = 9.5, 2.5 Hz, 1H), 6.46 (d, J = 1.3 Hz,1H), 4.86-4.72 (m, 1H), 3.59 (t, J = 5.0 Hz, 4H), 3.15 (s,6H), 3.06 (t, J = 5.0 Hz, 4H), 2.66-2.43 (m, 2H), 2.15-1.96(m, 4H), 1.85-1.64 (m, 2H), 1.48 (s, 9H). 13C NMR(101 MHz, CDCl3) delta 163.83, 154.53, 153.19, 151.76,151.55, 141.72, 139.75, 132.98, 126.73, 118.85, 113.68,113.18, 100.74, 80.24, 58.01, 49.49, 39.42, 35.20, 30.20,28.41, 24.61.
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Reference:
Article; Guo, Qingxiang; Li, Yongtao; Zhang, Chao; Huang, Zhi; Wang, Xin; Nie, Yongwei; Li, Yao; Liu, Yanhua; Yang, Shengyong; Xiang, Rong; Fan, Yan; Medicinal Chemistry Research; vol. 27; 6; (2018); p. 1666 – 1678;,
Pyrimidine | C4H4N2 – PubChem,
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