Yamashita, Junko; Hirata, Yukio published the article 《Running fits and γ-aminobutyric acid of the superior colliculus of the mouse》. Keywords: GABA brain running fit; convulsion GABA brain; vitamin B6 antagonist GABA.They researched the compound: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride( cas:148-51-6 ).Computed Properties of C8H12ClNO2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:148-51-6) here.
The γ-aminobutyric acid content of the superior colliculus of the mouse brain was decreased following the induction of running fits by the intracollicular injection of the antivitamin B6 compound semicarbazide. Aminooxyacetic acid hemihydrochloride, an inhibitor of 4-aminobutyrate-2-oxoglutarate aminotransferase (EC 2.6.1.19) with a resultant increase in GABA levels, has been shown to exert an antidotal effect on the induction of running fits. Therefore, this type of convulsive behavior is apparently associated with diminished levels of GABA in the superior colliculus. Running fits were also induced by the antivitamin B6 compounds thiosemicarbazide and 4-deoxypyridoxine-HCl, and presumedly this was also the result of a decrease in GABA level.
There is still a lot of research devoted to this compound(SMILES：OC1=C(C)C(CO)=CN=C1C.[H]Cl)Computed Properties of C8H12ClNO2, and with the development of science, more effects of this compound(148-51-6) can be discovered.
Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia