Makova, Barbara; Mik, Vaclav; Liskova, Barbora; Gonzalez, Gabriel; Vitek, Dominik; Medvedikova, Martina; Monfort, Beata; Rucilova, Veronika; Kadlecova, Alena; Khirsariya, Prashant; Gandara Barreiro, Zoila; Havlicek, Libor; Zatloukal, Marek; Soural, Miroslav; Paruch, Kamil; D’Autreaux, Benoit; Hajduch, Marian; Strnad, Miroslav; Voller, Jiri published an article in 2021. The article was titled 《Cytoprotective activities of kinetin purine isosteres》, and you may find the article in Bioorganic & Medicinal Chemistry.Electric Literature of C6H3Cl2N3 The information in the text is summarized as follows:
Kinetin (N6-furfuryladenine), a plant growth substance of the cytokinin family, has been shown to modulate aging and various age-related conditions in animal models. Here, the authors report the synthesis of kinetin isosteres with the purine ring replaced by other bicyclic heterocycles, and the biol. evaluation of their activity in several in vitro models related to neurodegenerative diseases. The findings indicate that kinetin isosteres protect Friedreichs ataxia patient-derived fibroblasts against glutathione depletion, protect neuron-like SH-SY5Y cells from glutamate-induced oxidative damage, and correct aberrant splicing of the ELP1 gene in fibroblasts derived from a familial dysautonomia patient. Although the mechanism of action of kinetin derivatives remains unclear, this data suggest that the cytoprotective activity of some purine isosteres is mediated by their ability to reduce oxidative stress. Further, the studies of permeation across artificial membrane and model gut and blood-brain barriers indicate that the compounds are orally available and can reach the central nervous system. Overall, the data demonstrate that isosteric replacement of the kinetin purine scaffold is a fruitful strategy for improving known biol. activities of kinetin and discovering novel therapeutic opportunities. In the part of experimental materials, we found many familiar compounds, such as 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4Electric Literature of C6H3Cl2N3)
2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4) belongs to pyrimidine. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. Electric Literature of C6H3Cl2N3
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia