Ouyang, Yao; Xu, Xiu-Hua; Qing, Feng-Ling published the artcile< Trifluoromethanesulfonic Anhydride as a Low-Cost and Versatile Trifluoromethylation Reagent>, Recommanded Product: 2,4-Dichlorothieno[2,3-d]pyrimidine, the main research area is fluoromethanesulfonic anhydride fluoromethylation reagent photoredox catalysis pyridine activation; photoredox catalysis; pyridine; radical; trifluoromethanesulfonic anhydride; trifluoromethylation.
A large number of reagents have been developed for the synthesis of trifluoromethylated compounds However, an ongoing challenge in trifluoromethylation reaction is the use of less expensive and practical trifluoromethyl sources. We report herein the unprecedented direct trifluoromethylation of (hetero)arenes using trifluoromethanesulfonic anhydride as a radical trifluoromethylation reagent by merging photoredox catalysis and pyridine activation. Furthermore, introduction of both the CF3 and OTf groups of the trifluoromethanesulfonic anhydride into internal alkynes to access tetrasubstituted trifluoromethylated alkenes was achieved. Since trifluoromethanesulfonic anhydride is a low-cost and abundant chem., this method provides a cost-efficient and practical route to trifluoromethylated compounds
Angewandte Chemie, International Edition published new progress about Alkynes, internal Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 18740-39-1 belongs to class pyrimidines, and the molecular formula is C6H2Cl2N2S, Recommanded Product: 2,4-Dichlorothieno[2,3-d]pyrimidine.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia