《A novel one-pot and efficient procedure for synthesis of new fused uracil derivatives for DNA binding》 was written by Mousa, Bothaina A.; Bayoumi, Ashraf H.; Korraa, Makarem M.; Assy, Mohamed G.; El-Kalyoubi, Samar A.. Electric Literature of C4HCl3N2This research focused onxanthine arylidineaniline indenopyrrolopyrimidine indenopteridine ninhydrin DNA damage nucleobase; hydrazone oxidative cyclization thionyl chloride pyrazolopyrimidine nitrosation aminouracil; DNA uracil fused synthesis hydrazinolysis chloromethyluracil condensation aromatic aldehyde. The article conveys some information:
Hydrazinolysis of 6-chloro-1-methyluracil followed by condensation of the product with different aromatic aldehyde gives the resp. hydrazones which undergoes oxidative cyclization using thionyl chloride to obtain pyrazolo[3,4-d]pyrimidines in good yields. On the other hand, nitrosation of 6-aminouracils followed by the reaction with different arylidineanilines gives new xanthine derivatives Finally, indenopyrrolopyrimidine and indenopteridine are obtained in good yields via the reaction of 6-aminouracils and 5,6-diaminouracil with ninhydrin resp. The newly synthesized compounds show binding, chelation and fragmentation of the nucleic acid DNA. The experimental part of the paper was very detailed, including the reaction process of 2,4,6-Trichloropyrimidine(cas: 3764-01-0Electric Literature of C4HCl3N2)
2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Electric Literature of C4HCl3N2
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia