Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. 4595-59-9, formula is C4H3BrN2, Name is 5-Bromopyrimidine. In nucleic acids, three types of nucleobases are pyrimidine derivatives: cytosine (C), thymine (T), and uracil (U). Synthetic Route of 4595-59-9.
Casimiro-Garcia, Agustin;Allais, Christophe;Brennan, Agnes;Choi, Chulho;Dower, Gabriela;Farley, Kathleen A.;Fleming, Margaret;Flick, Andrew;Frisbie, Richard K.;Hall, Justin;Hepworth, David;Jones, Hannah;Knafels, John D.;Kortum, Steve;Lovering, Frank E.;Mathias, John P.;Mohan, Sashi;Morgan, Paul M.;Parng, Chuenlei;Parris, Kevin;Pullen, Nick;Schlerman, Franklin;Stansfield, John;Strohbach, Joseph W.;Vajdos, Felix F.;Vincent, Fabien;Wang, Hong;Wang, Xiaolun;Webster, Robert;Wright, Stephen W. research published 《 Discovery of a Series of Pyrimidine Carboxamides as Inhibitors of Vanin-1》, the research content is summarized as follows. A diaryl ketone series was identified as vanin-1 inhibitors from a high-throughput screening campaign. While this novel scaffold provided valuable probe 2 that was used to build target confidence, concerns over the ketone moiety led to the replacement of this group. The successful replacement of this moiety was achieved with pyrimidine carboxamides derived from cyclic secondary amines that were extensively characterized using biophys. and crystallog. methods as competitive inhibitors of vanin-1. Through optimization of potency and physicochem. and ADME properties, and guided by co-crystal structures with vanin-1, 3 was identified with a suitable profile for advancement into preclin. development.
Synthetic Route of 4595-59-9, 5-Bromopyrimidine is a reactive intermediate that is used in the synthesis of 4-methoxyphenylboronic acid. 5-Bromopyrimidine has been shown to be nucleophilic, reacting with β-amino acids under basic conditions to form the corresponding 2-bromo amide. It also undergoes cross-coupling reactions with halides and can be used as a building block for other organic compounds. 5-Bromopyrimidine has optical properties that are characteristic of aromatic molecules, including strong absorption bands in the ultraviolet region and visible light region.
5-Bromopyrimidine undergoes direct metallation with lithuium diisopropylamide to yield 4-lithio-5-bromopyrimidine., 4595-59-9.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia