So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Yakovleva, N. L.; Balyakina, M. V.; Gunar, V. I. researched the compound: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride( cas:148-51-6 ).SDS of cas: 148-51-6.They published the article 《Amino derivatives of pyridoxine and its analogs》 about this compound( cas:148-51-6 ) in Khimiko-Farmatsevticheskii Zhurnal. Keywords: pyridoxine amino; aminopyridoxine. We’ll tell you more about this compound (cas:148-51-6).
Treatment of pyridines I (R = OH, R1 = Me, R2 = CH2OH (II); RR1 = OCMe2CH2O, R2 = CH2OH; R = OH, R1 = CH2OH, R2 = Me) with OP(NMe2)3 gave III (R = OH, R1 = Me, R2 = CH2NMe2 (IV); R = OH, R1 = CH2OH, R2 = CH2NMe2; R = OH, R1 = CH2 NMe2, R2 = Me). Heating II with SOCl2 gave I (R = OH, R1 = Me, R2 = CH2Cl), which was transformed to IV by reaction with Me2NH. Reaction of I (R3 = Cl) with HNMe2 gave I (R3 = NMe2).
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Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia