The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1192813-64-1, name is 2-Chloro-5-(difluoromethoxy)pyrimidine. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 1192813-64-1
16. Reaction of 2-chloro-5-(difluoromethoxy)pyrimidine with zinc cyanide, tris(dibenzylideneacetone)dipalladium(0), 1 , 1 ‘-bis(diphenylphosphino)ferrocene, and zinc dust in Lambda/,/V-dimethylacetamide at elevated temperature provided 5- (difluoromethoxy)pyrimidine-2-carbonitrile. This material was hydrolyzed with aqueous sodium hydroxide solution to afford the requisite 5-(difluoromethoxy)pyrimidine-2- carboxylic acid.
With the rapid development of chemical substances, we look forward to future research findings about 1192813-64-1.
Reference:
Patent; PFIZER INC.; BRODNEY, Michael Aaron; BECK, Elizabeth Mary; BUTLER, Christopher Ryan; ZHANG, Lei; O’NEILL, Brian Thomas; BARREIRO, Gabriela; LACHAPELLE, Erik Alphie; ROGERS, Bruce Nelsen; WO2015/155626; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia