Synthetic Route of 14631-08-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 14631-08-4, name is 2-Chloropyrimidine-4,5-diamine. This compound has unique chemical properties. The synthetic route is as follows.
EXAMPLE 6; (2-{4-[2-(Trifluoromethyl)phenoxylpiperidin-l-yl}-9H-purin-8-yl)methanol; Step 1: 2-{4-[2-(Trifluoromethyl)phenoxylpiperidin-l-yl}pyrimidine-4,5-diamine; A mixture of 2-chloropyrimidine-4,5-diamine (200 mg, 1.4 mmol), 4-[2- (trifluoromethyl)phenoxy]piperidine (0.4 mL, 1.6 mmol) and triethylamine (0.58 mL, 4.1 mmol) in 2-methoxyethanol/water (4:1, 2.8 mL) was heated at 13O 0C for 16 h. The solvent was evaporated, diluted with water (5 mL) and extracted three times with EtOAc (5 mL). The combined organic layers were dried over Na2SO4. Evaporation of the solvent followed by purification by Combiflash (SiO2, 5 % MeOeta/EtOAc) afforded the title compound as a solid. MS (+ESI) m/z 354 (MH+).
According to the analysis of related databases, 14631-08-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MERCK FROSST CANADA LTD.; WO2008/17161; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia