Related Products of 216309-28-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 216309-28-3, name is 5-((Trimethylsilyl)ethynyl)pyrimidine, molecular formula is C9H12N2Si, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
S8b) 3,-Dideoxy-3-i4-(l,3-pyrimidin-5-yl)-lH-l,2,3-triazol-l-yll-3,-i4-(3,4,5- trifluorophenyl)-lH-l,2,3-triazol-l-yll-l.,l ‘-sulfanediyl-di-B-D-galactopyranosideIntermediate 1 (92 mg) and 5-[2-(trimethylsilyl)ethynyl]-pyridine (65 mg) was dissolved in MeCN (5 mL, dry) and stirred at r.t. Copper(I) iodide (24 mg) was added followed by Hunig’s base (65 mu) and the mixture was heated to 50 C. After 18 h cesium fluoride (5 mg) was added and the temperature increased to 70 C. After 24 h the mixture was filtered and concentrated. The residue was purified by HPLC (Xterra/MeCN:H20:25 mM NH3). Freezedrying afforded the title compound as a white solid (73 mg). H NMR (400 MHz, Methanol-i4) delta 9.24 (s, 2H), 9.13 (s, 1H), 8.76 (s, 1H), 8.58 (s, 1H), 7.65 – 7.56 (m, 2H), 5.01 – 4.88 (m, 4H), 4.75 (q, J= 10.3 Hz, 2H), 4.17 (dd, J = 8.7, 2.4 Hz, 2H), 3.95 – 3.78 (m, 4H), 3.73 (dd, J= 11.3, 3.5 Hz, 2H). ESI-MS m/z calcd for [C26H28F3N808S]+(M+H)+: 669.16; found: 669.15.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 216309-28-3, 5-((Trimethylsilyl)ethynyl)pyrimidine.
Reference:
Patent; GALECTO BIOTECH AB; ZETTERBERG, Fredrik; NILSSON, Ulf; LEFFLER, Hakon; BRIMERT, Thomas; JOHNSSON, Richard; VERMA, Priya; (71 pag.)WO2016/113335; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia