With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.16097-60-2, name is 2-Amino-4-chloro-6-(trifluoromethyl)pyrimidine, molecular formula is C5H3ClF3N3, molecular weight is 197.55, as common compound, the synthetic route is as follows.Formula: C5H3ClF3N3
Example 19 N4-{4-[(3-Chloro-1H-pyrrolo[2,3-b]pyridin-4-yl)methyl]-3-fluorophenyl}-6-(trifluoromethyl)pyrimidine-2,4-diamine 185 mg (0.60 mmol) of 4-[(3-chloro-1H-pyrrolo[2,3-b]pyridin-4-yl)methyl]-3-fluoroaniline and 130 mg (0.66 mmol) of 4-chloro-6-(trifluoromethyl)pyrimidine-2-amine are suspended in 4 ml of water and 0.30 ml of 4N hydrochloric acid. The reaction mixture is heated at reflux for 2 hours. After cooling, the mixture is made alkaline using dilute aqueous sodium hydroxide solution, a little methanol is added and the mixture is extracted with ethyl acetate. The extract is dried over sodium sulfate and the solvent is removed under reduced pressure. The residue is purified by preparative HPLC. This gives crystals. Yield: 123 mg (45% of theory) LC-MS (Method 1): Rt=2.32 min. MS (ESI pos.): m/z=437 [M+H]+. 1H-NMR (DMSO-d6, 400 MHz): delta=4.47 (s, 2H), 6.35 (s, 1H), 6.76 (d, 1H), 6.94 (br. s, 2H), 7.03 (t, 1H), 7.29 (dd, 1H), 7.64 (s, 1H), 7.93 (dd, 1H), 8.18 (d, 1H), 9.75 (s, 1H), 12.00 (s, 1H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,16097-60-2, 2-Amino-4-chloro-6-(trifluoromethyl)pyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; Bayer HealthCare AG; US2008/269268; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia