Extracurricular laboratory: Synthetic route of 2-Chloro-5-(cyclopropylmethoxy)pyrimidine

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,169677-66-1, its application will become more common.

Synthetic Route of 169677-66-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 169677-66-1, name is 2-Chloro-5-(cyclopropylmethoxy)pyrimidine. A new synthetic method of this compound is introduced below.

80.0 mg (0.28 mmol) of the amine VII.1, 55.8 mg (0.28 mmol) of example XII.4 and 144 muL (0.84 mmol) DIPEA in 2 mL NMP are stirred at 100 C. for 30 min. The reaction mixture is directly purified by HPLC (ACN/H2O/NH3).For example 6.7 the reaction conditions are 150 C. over night.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,169677-66-1, its application will become more common.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; FLECK, Martin; HEIMANN, Annekatrin; HEINE, Niklas; NOSSE, Bernd; ROTH, Gerald Juergen; US2014/315882; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia