Reference of 90856-77-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 90856-77-2 as follows.
3.0 g (7.0 mmol) of Intermediate I-3-2 and 80 ml of toluene were added to a reactor, and then, 0.4 g (3.3 mmol) of 4,6-dimethylpyrimidin-5-amine, 0.1 g (0.5 mmol) of Pd(dba)2, 0.2 g (1.0 mmol) of P(tBu)3, and 0.95 g (9.9 mmol) of sodium butoxide were added thereto. The mixture was then heated and stirred under reflux at a temperature of 120 C. for 36 hours. When the reaction was completed, the resulting mixture was concentrated under reduced pressure, dissolved in dichloromethane, and filtered using diatomite. The organic layer obtained therefrom was dried by using magnesium sulfate to be distilled under reduced pressure, and purified by liquid chromatography to obtain 1.4 g (1.7 mmol, yield: 53%) of Intermediate I-3-1. LC-MS m/z=814 (M+H)+
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,90856-77-2, its application will become more common.
Reference:
Patent; Samsung Electronics Co., Ltd.; CHOI, Jongwon; ARATANI, Sukekazu; LEE, Kum Hee; LEE, Banglin; CHOI, Hyeonho; KWAK, Seungyeon; KWAK, Yoonhyun; KIM, Sangdong; KIM, Jiwhan; BAIK, Chul; CHO, Yongsuk; (115 pag.)US2019/74457; (2019); A1;,
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