Adding a certain compound to certain chemical reactions, such as: 163263-91-0, 2,4-Dichloro-6-(4-methoxyphenyl)pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C11H8Cl2N2O, blongs to pyrimidines compound. HPLC of Formula: C11H8Cl2N2O
1H-NMR (300 MHz, CDCl3): delta (ppm) 8.91 (d, J= 3.0 Hz, 1H), 8.76 (m, 4H), 8.39 (d, J = 9.0 Hz, 2H), 7.92 (m, 2H), 7.58-7.38 (t, J = 8.0 Hz, 2H), and 7.06(d, J = 9.0 Hz, 2H), 3.91 (s, 3H); 13C-NMR (75 MHz, DMSO-d6): delta (ppm) 165.2, 163.9, 163.6, 162.1, 155.6,154.4, 150.1, 149.4, 137.1, 136.8, 129.5, 129.2, 125.6, 124.6, 124.1, 122.4, 114.2, 111.1, and 55.4; and LRMS(ESI-MS) m/z = 341.13 [M + H]+In a dry round-bottomed flask, 2,4-dichloro-6-(4-methoxyphenyl)pyrimidine (677 mg, 2.65mmol, 1.0 eq) and Pd(Ph3)4 (460 mg, 0,39 mmol, 0.15 eq) are introduced under argon atmosphere. Dry toluene (20 mL) is added, and a cooling system is installed. The mixture is degassed for 10 min before the addition of 2-(tributylstannyl)pyridine (2.1 mL, 6.63 mmol, 2.5 eq) and heated at reflux (110 C)for 15 h. Then, 30 mL of water is added. The crude mixture is filtrated on a pad of celite and washed with ethyl acetate, followed by extraction. The combined organic phase is dried over MgSO4, filtered and concentrated to dryness. The product is purified by column chromatography (Al2O3-cyclohexane/AcOEt 50/50) to afford the expected product (749 mg, 83%).
The synthetic route of 163263-91-0 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Morel, Elodie; Beauvineau, Claire; Naud-Martin, Delphine; Landras-Guetta, Corinne; Verga, Daniela; Ghosh, Deepanjan; Achelle, Sylvain; Mahuteau-Betzer, Florence; Bombard, Sophie; Teulade-Fichou, Marie-Paule; Molecules; vol. 24; 3; (2019);,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia