Reference of 52854-14-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 52854-14-5, name is 4-Chloro-6-methoxy-5-nitropyrimidine. This compound has unique chemical properties. The synthetic route is as follows.
The above product (3.50 g, 18.5 mmol) and 3′-aminobiphenyl-2-carbonitrile (prepared according to the procedure described in WO 02/38568) (3.23 g, 16.6 mmol) were dissolved in triethylamine (9. 32 g, 92.3 mmol) and dimethylsulfoxide (10 ml) and heated at 90C for 18 h. The mixture was allowed to cool to ambient temperature then poured onto water (150 ml) and extracted with ethyl acetate (2 x 300 ml). The organic fractions were combined, washed with water (3 x 75 ml) and brine (50 ml), dried over anhydrous sodium sulfate, filtered and evaporated to give a brown solid. The brown solid was triturated with diethyl ether (50 ml), filtered, washed with diethyl ether (2 x 10 ml) and left to air dry, which gave 3′- (1-methyl-5-nitro-6-oxo-1, 6-DIHYDROPYRIMIDIN-4-YLAMINO) biphenyl-2-carbonitrile (2.24 g, 38%) as a yellow solid
According to the analysis of related databases, 52854-14-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MERCK SHARP & DOHME LIMITED; WO2004/41826; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia