Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2927-71-1, name is 2,4-Dichloro-5-fluoropyrimidine. This compound has unique chemical properties. The synthetic route is as follows. category: pyrimidines
Nitrogen was bubbled into a solution of compound 13 (1 g, 6 mmol, 1.1 eq), Pd(dppf)2Cl2 (0.38 g, 0.05 mmol, 0.1 eq) and 2 N Na2C03 (8.4 mL, 16.8 mmol, 3 eq) in DME (17 mL) for 5 minutes. The mixture was warmed to 80 C and a solution of compound 12 (1.8 g, 5.4 mmol, 1 eq) in DME (18 mL) was added dropwise. After addition, the mixture was stirred at 84 C for 1 h. After cooling down to rt, the mixture was diluted with ethyl acetate (100 mL) and washed with brine (50 mL x 2), dried over sodium sulfate, concentrated and purified by column chromatography to give the desired product (1.8 g, 60%). LCMS: (M+H)+: 334.8.
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Reference:
Patent; BEIJING XUANYI PHARMASCIENCES CO., LTD.; SONG, Yuntao; CHEN, Xiaoqi; (188 pag.)WO2019/35008; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
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