Synthetic Route of 3438-46-8, Adding some certain compound to certain chemical reactions, such as: 3438-46-8, name is 4-Methylpyrimidine,molecular formula is C5H6N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3438-46-8.
To A SUSPENSION OF NAH (2. 26 G 50%, 47. 7 MMOL) IN DMF (92 ML) UNDER ARGON atmosphere and cooled to 0 C, 4-METHYLPYRIMIDINE (3. 00 G, 31. 9 MMOL) WAS added SLOWLY. THEN, ETHYL 4-FLUOROBENZOATE (6. 40 G, 38. 2 MMOL) WAS ADDED AND IT was stirred at room temperature overnight. Water was added and the solvent was evaporated. The residue was taken up in A mixture of ETOAC and brine. The phases were separated and the aqueous phase was REEXTRACTED with ETOAC. The combined organic PHASES WERE DRIED OVER NA2S04 AND CONCENTRATED TO DRYNESS. The crude PRODUCT OBTAINED BY CHROMATOGRAPHY ON SILICA GEL USING HEXANE-ETOAC mixtures OF INCREASING POLARITY AS ELUENT, TO AFFORD 3. 30 G OF THE DESIRED COMPOUND (YIELD : 48%). H NMR (300 MHZ, CDCI3) 8 (TMS) : 4. 11 (KETONE : S, 2 H), 5. 94 (ENOL : S, 1 H), 6. 94 (ENOL : D, J = 5. 4 HZ, 1 H), 7. 08-7. 16 (M, 2 H), 7. 37 (KETONE : D, J = 5. 1 HZ, 1 H), 7. 89 (ENOL : M, 2 H), 8. 08 (KETONE : M, 2 H), 8. 42 (ENOL : D, J = 5. 4 HZ, 1 H), 8. 69 (KETONE : D, J = 5. 1 HZ, 1 H), 8. 81 (ENOL : S, 1 H), 9. 17 (KETONE : S, 1 H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 3438-46-8, 4-Methylpyrimidine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; J. URIACH Y COMPANIA S.A.; WO2004/76450; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia