Application of 183438-24-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 183438-24-6, name is 5-Bromo-2-iodopyrimidine. This compound has unique chemical properties. The synthetic route is as follows.
To a clean and dry reactor containing 20.04 g of isopropyl 2-bromo-3-cyclopentyl-1-methyl-1H-indole-6-carboxylate, 1.06 g of Pd(TFP)2Cl2 (3 mol %) and 0.76 g of tri(2-furyl)phosphine (6 mol %) was charged 8.35 g of triethylamine (1.5 equivalent), 39.38 g of CH3CN at 23±10 C. under nitrogen or argon and started agitation for 10 min 9.24 g of 4,4,5,5-tetramethyl-1,3,2-dioxaborolane was charged into the reactor. The mixture was heated to reflux (ca. 81-83 C.) and stirred for 6 h until the reaction completed. The batch was cooled to 30±5 C. and quenched with a mixture of 0.99 g of water in 7.86 g of CH3CN. 17.24 g of 5-bromo-2-iodopyrimidine and 166.7 g of degassed aqueous potassium phosphate solution (pre-prepared from 46.70 g of K3PO4 and 120 g of H2O) was charged subsequently under argon or nitrogen. The content was heated to reflux (ca. 76-77 C.) for 2 h until the reaction completed. 4.5 g of 1-methylimidazole was charged into the reactor at 70 C. The batch was cooled to 20±3 C. over 0.5 h and hold at 20±3 C. for at least 1 h. The solid was collected by filtration. The wet cake was first rinsed with 62.8 g of 2-propanol, followed by 200 g of H2O. The solid was dried under vacuum at the temperature below 50 C. [0095] Into a dry and clean reactor was charged dried I, 10 wt % Norit SX Ultra and 5 V of THF. The content was heated at 60±5 C. for at least 1 h. After the content was cooled to 35±5 C., the carbon was filtered off and rinsed with 3 V of THF. The filtrate was charged into a clean reactor containing 1-methylimidazole (10 wt % relative to I). After removal of 5 V of THF by distillation, the content was then cooled to 31±2 C. After the agitation rate was adjusted to over 120 rpm, 2.5 V of water was charged over a period of at least 40 minutes while maintaining the content temperature at 31±2 C. After the content was agitated at 31±2 C. for additional 20 min, 9.5 V of water was charged into the reactor over a period of at least 30 minutes at 31±2 C. The batch was then cooled to about 25±3 C. and stirred for additional 30 minutes. The solid was collected and rinsed with 3 V of water. The wet product I was dried under vacuum at the temperature below 50 C. (19.5 g, 95 wt %, 76% yield).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 183438-24-6, 5-Bromo-2-iodopyrimidine.
Reference:
Patent; Boehringer Ingelheim International GmbH; LI, Zhibin; YANG, Bing-Shiou; YIP, Kazuhiko; US2013/261134; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia