Application of 22276-99-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 22276-99-9, name is 4-Amino-5-bromo-1H-pyrrolo[2,3-d]pyrimidine, molecular formula is C6H5BrN4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
(S)-(4-Oxo-3-(1 -phenylethyl)-3,4-dihydropyrrolo[2, 1 -f][1 ,2,4]triazin-2-yl)methyl methanesulfonate (295 mg, 0.67 mmol) was dissolved in 5 ml_ dimethylformamide. 5- Bromo-7/-/-pyrrolo[2,3-d]pyrimidin-4-amine (156 mg, 0.73 mmol) and potassium carbonate (184 mg, 1.33 mmol) were added. The mixture was stirred at room temperature overnight. The crude was poured over water and the precipitate was filtered and washed with water to give the title compound (239 mg, 55%) as a white solid. Purity 70%
According to the analysis of related databases, 22276-99-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ALMIRALL, S.A.; GRACIA FERRER, Jordi; CARRASCAL RIERA, Marta; ERRA SOLA, Montserrat; WO2014/60431; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia