Application of 1195-08-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1195-08-0, name is 2,4-Dioxo-1,2,3,4-tetrahydropyrimidine-5-carbaldehyde, molecular formula is C5H4N2O3, molecular weight is 140.1, as common compound, the synthetic route is as follows.
To a DMF (0.35 M) solution of 5-formyluracil (1 eq.) was added sequentially at O0C 1 – 5 bromo-3-methoxypropane (2.2 eq.) and DBU (2.2 eq.). The resulting solution was stirred at RT for 72 h. The volatiles were then removed in vacuo. The crude product mixture thus obtained was directly subjected to purification by way of column chromatography (SiCb, EtOAc) to afford the title compound as a yellow oil.
The chemical industry reduces the impact on the environment during synthesis 1195-08-0, I believe this compound will play a more active role in future production and life.
Reference:
Patent; MERCK FROSST CANADA LTD.; WO2009/140769; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia