Application of 2227-98-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2227-98-7, name is 4-Aminopyrrolo[3,2-d]pyrimidine, molecular formula is C6H6N4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of 1 -((4RS, 5RS)-2,2-dimethyM-(methylthiomethyl)-1 ,3-dioxan-5-yl)-lambda/- methylmethanamine (30 mg, 137 mumol) in dioxane (2 mL) and water (0.5 mL) was added 9-deazaadenine (27.5 mg, 205 mumol) and 37% aqueous formaldehyde (15.86 mul,205 mumol). The reaction mixture was heated at 85 0C for 15 mins and then cooled and7N NH3ZMeOH (2.5 mL) was added. The solution was allowed to stand at RT for 3 days and concentrated to dryness. Chromatography (10% 7N NH3/MeOH in CH2CI2) gave 7-(((((4RS,5RS)-2,2-dimethyM-(methylthiomethyl)-1 ,3-dioxan-5- yl)methyl)(methyl)amino)methyl)-5H-pyrrolo[3,2-cdpyrimidin-4-amine (34 mg, 93 mumol,68 % yield) as a syrup. 1H NMR (CD3OD) delta 8.16 (1H, s); 7.45 (1H, s); 3.86 (1H, dd, J= 5.2, 11.9 Hz); 3.73-3.58 (3H, m); 3.52 (1 H1 dd, J = 10.6, 11.7 Hz); 2.79 (1 H, dd, J =2.5, 14.0 Hz); 2.53 (1H, dd, J = 7.1, 14.0 Hz); 2.32 (1H, dd, J = 5.5, 12.7 Hz); 2.24 (3H, s); 2.16 (1H, dd, J = 8.1 , 12.4 Hz); 2.06 (3H, s); 2.03-1.96 (1H, m); 1.36 (3H, s); 1.31(3H. s). 13C NMR (CD3OD) delta 152.6, 151.4, 147.8, 130.6, 115.7, 113.4, 100.1 , 75.9,64.7, 57.3, 52.4, 43.6, 39.3, 38.3, 29.9, 20.4, 17.4.
According to the analysis of related databases, 2227-98-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; INDUSTRIAL RESEARCH LIMITED; ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY; WO2008/30118; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia