Electric Literature of 62846-82-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 62846-82-6, name is Ethyl 4-pyrimidinecarboxylate. This compound has unique chemical properties. The synthetic route is as follows.
General Procedure 14 was followed in the preparation of Intermediate 21. 2149 General Procedure 14 2151 Intermediate 19 Intermediate 21 2152 [0246] Intermediate 19 (1.6 g, 10.5 mmol) was added dropwise to a vigorously stirring 2153 mixture of aminoguanidine sulfate (10.3 g, 42.1 mmol, 4 eq) in freshly prepared NaOMe 2154 (using 968 mg, 42.1 mmol of Na in 28 mL of dry MeOH) at 0 C. The resulting mixture was 2155 heated to reflux for 20 h. The mixture was then cooled to RT, carefully poured over ice cold 2156 water (20 mL) and concentrated in vacuo. The crude residue was purified over neutral 2157 alumina using 4-10% MeOH-CHCl3 as the eluent to give Intermediate 21 (5 OOmg, 26%) . 2158 MS: 163 [M + H]+; TLC: 20% MeOH in CHC13: Rf: 0.20.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 62846-82-6, Ethyl 4-pyrimidinecarboxylate.
Reference:
Patent; VERSEON, INC.; SHORT, Kevin, Michael; PHAM, Son, Minh; WILLIAMS, David, Charles; KITA, David, Ben; WO2014/145986; (2014); A1;,
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