With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1211443-61-6, name is 2-Chloro-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide, molecular formula is C14H17ClN4O, molecular weight is 292.76, as common compound, the synthetic route is as follows.SDS of cas: 1211443-61-6
2-Chloro-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-6-carboxamide (500 mg, 1.71 mmol) was suspended in 20 mL of 1,4 – in dioxane,2-Amino-5-nitropyridine (356 mg, 2.56 mmol), Pd(OAc) 2 (9.6 mg, 0.043 mmol),BINAP (53 mg, 0.09 mmol) and Cs2CO3 (834 mg, 2.56 mmol) were applied to argon for 3 times and warmed to 100 C overnight.After cooling to room temperature, the reaction mixture was concentrated under reduced pressure.The crude silica gel column was chromatographed to give 200 mg of desired product 3-7.Yellow solid with a yield of 30%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1211443-61-6, 2-Chloro-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide, and friends who are interested can also refer to it.
Reference:
Patent; Nankai University; Xiang Rong; Fan Yan; Li Yongtao; Guo Qingxiang; Huang Zhi; Wang Xin; Zhang Chao; Liu Yanhua; (32 pag.)CN108929324; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia