Introduction of a new synthetic route about 2,5-Dibromopyrimidine

According to the analysis of related databases, 32779-37-6, the application of this compound in the production field has become more and more popular.

Related Products of 32779-37-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 32779-37-6, name is 2,5-Dibromopyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

j0120] To a solution of2-(4-fluorophenyl)ethanol (0.566 g) in TRF (10 mE) was added NaR (0.269 g). The mixture was stirred at room temperature for 2 hours, before 2,5-dibro- mopyrimidine (0.8 g) was added. The mixture was stirred at room temperature for 16 h. The reaction was quenched with water and extracted with EtOAc (2×20 mE). The organic layers were combined, dried over MgSO4 and concentrated under vacuum. The residue was purified by silica gel column (Rex/EtOAc=1 00:5) to give 5-bromo-2-(4-fluoropheneth- oxyl)pyrimidine (0.7 g). ECMS (M+R)=297.0.

According to the analysis of related databases, 32779-37-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Bristol-Myers Squibb Company; Naidu, B. Narasimhulu; Patel, Manoj; Romine, Jeffrey Lee; St. Laurent, Denis R.; Wang, Tao; Zhang, Zhongxing; Kadow, John F.; US2015/232463; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia