Synthetic Route of 1374639-77-6 ,Some common heterocyclic compound, 1374639-77-6, molecular formula is C12H14ClN3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
A solution of compound(4) (4 g, 15.9 mmol) in THF (60 mL) was stirred at 10-15 Cunder nitrogen atmosphere, manganese(IV)oxide (2.8 g, 31.7mmol) was added to the mixture and stirring was continuedfor 2 hours at 29 C. Progress of the reaction was monitoredby TLC. After completion of the reaction, the resultingmixture was filtered through celite bed and concentratedunder vacuum. The crude product was purified by columnchromatography using 2% of ethyl acetate and hexane aseluent to obtain compound (5). White crystalline solid,Yield: 72%, 152-154 C. 1H NMR (400 MHz, DMSO-d6):1.65-1.68 (m, 2H, -CH2), 1.99-2.03 (m, 4H, CH2), 2.14-2.16(m, 2H, CH2), 5.60-5.68 (m, 1H, -NH-CH-), 7.72 (s, 1H, Ar-H), 9.92 (s, 1H, Ar-H), 9.98 (s, 1H, CHO). 13C NMR (75.46MHz, DMSO-d6): 184.6, 156.6, 153.5, 137.5, 130.1, 116.9,56.3, 31.03, 24.9. ESI-HRMS (m/z): Calcd. ForC12H12ClN3O:249.6969. Found: m/z 249.0971 [M+].
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1374639-77-6, (2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)methanol, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Singaram, Kulathooran; Marimuthu, Dhamodaran; Baskaran, Selvakumar; Chinaga, Suresh K.; Shanmugarajan, Dhivya; Vadivel, Thangavel; Combinatorial Chemistry and High Throughput Screening; vol. 20; 8; (2017); p. 703 – 712;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia