Adding a certain compound to certain chemical reactions, such as: 4316-98-7, 6-Chloro-4,5-diaminopyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C4H5ClN4, blongs to pyrimidines compound. Computed Properties of C4H5ClN4
8-(4-((1H-pyrazol-1-yl)methyl)benzyl)-6-chloro-7H-purineCombined 2-[4-(1H-pyrazol-1-ylmethyl)phenyl]acetic acid (Fichert, Thomas; Yazdanian, Mehran; Proudfoot, John R. Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, 4 p. 719-722)(400.00 mg; 1.85 mmol; 1.00 eq.) and 6-chloropyrimidine-4,5-diamine (267.42 mg; 1.85 mmol; 1.00 eq.) in POCl3 (5.00 ml). Heated the reaction to 90 C. for 3 hours. Let the reaction cool to rt. Concentrated. Diluted with water, neutralized with sat?d NaHCO3, and extracted with ethyl acetate. Combined organics, dried with MgSO4, filtered, and concentrated. Purified by Biotage silica gel column to afford 8-(4-((1H-pyrazol-1-yl)methyl)benzyl)-6-chloro-7H-purine (319 mgs; 53%). MS (M+H)+ found for C16H13ClN6 : 325.0.
The synthetic route of 4316-98-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Global Blood Therapeutics, Inc.; Li, Zhe; Xu, Qing; Yu, Chul; Yee, Calvin; Gwaltney,, II, Stephen L.; Metcalf, Brian W.; Richards, Steven; Lardy, Matthew A.; Setti, Lina; Sham, Hing; US2015/315198; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia