Reference of 3934-20-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 3934-20-1, name is 2,4-Dichloropyrimidine. A new synthetic method of this compound is introduced below.
In a N2 atmosphere at 0 C for 10 minutes,CH3MgBr (3M in diethyl ether, 22.68 mL,68.03 mmol) was added dropwise to a stirred solution of 1-H-indole (7.97 g, 68.03 mmol) in 1,2-dichloroethane (250 mL).The resulting solution was stirred for 15 minutes and then 2,4-dichloropyrimidine (15.00 g, 100.69 mmol) was added in one portion. The resulting solution was allowed to warm to room temperature and stirred for additional 16 hours.The reaction was quenched by the addition of CH 3OH (25 mL) and then the mixture was concentrated in vacuo and applied to silica gel. Purification by FCC,Elution with 0-20% CH3OH in CH2Cl2,The title compound (7.17 g, 46%)
At the same time, in my other blogs, there are other synthetic methods of this type of compound,3934-20-1, 2,4-Dichloropyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; Jiao Yuqi; (26 pag.)CN108929311; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia