Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1088994-22-2, name is 5-Methyl-2-(pyrimidin-2-yl)benzoicacid. A new synthetic method of this compound is introduced below., COA of Formula: C12H10N2O2
5-Methyl-2-(pyrimidin-2-yl)benzoic acid (1.47 g; 6.86 mmol) is dissolved in DCM (50 ml) anddimethylaminopyridine (168 mg, 1.37 mmol) and EDC (1.45 g; 7.55 mmol) are added.Stirring is continued for 30 minutes followed by the addition of (S)-5-bromo-7-methyl-2-(2-methylpyrrolidin-2-yl)-1H-benzo[d]imidazole hydrochloride (2.27 g; 6.86 mmol). Stirring at RT is continued for 16 hours. Ethylacetate (150 ml) and sat. sodium hydrogencarbonate solution (100 ml) are added to the reaction mixture. The phases are separated and the aq. phase is extracted with EtOAc (50 ml). The combined organic layers are dried with Mg504, filteredand the solvent is evaporated under reduced pressure. The product is purified by preparative HPLC (conditions C) to give 2.07 g of the title compound as a white powder; tR [mm] = 0.73; [M+H] = 492.14.
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Reference:
Patent; ACTELION PHARMACEUTICALS LTD; BOSS, Christoph; BRISBARE-ROCH, Catherine; BROTSCHI, Christine; GUDE, Markus; HEIDMANN, Bibia; JENCK, Francois; SIFFERLEN, Thierry; STEINER, Michel; WILLIAMS, Jodi; WO2015/83094; (2015); A1;,
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